8sg1

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m (Protected "8sg1" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8sg1 is ON HOLD
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==Cryo-EM structure of CMKLR1 signaling complex==
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<StructureSection load='8sg1' size='340' side='right'caption='[[8sg1]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8sg1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SG1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sg1 OCA], [https://pdbe.org/8sg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sg1 RCSB], [https://www.ebi.ac.uk/pdbsum/8sg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sg1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CML1_HUMAN CML1_HUMAN] Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed:27716822). Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism.<ref>PMID:15728234</ref> <ref>PMID:15753205</ref> <ref>PMID:20044979</ref> <ref>PMID:27716822</ref> (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).<ref>PMID:9603476</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Zhang C]]
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[[Category: Zhang X]]

Revision as of 13:14, 1 November 2023

Cryo-EM structure of CMKLR1 signaling complex

PDB ID 8sg1

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OCA

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