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1jsu
From Proteopedia
(New page: 200px<br /> <applet load="1jsu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jsu, resolution 2.3Å" /> '''P27(KIP1)/CYCLIN A/C...) |
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| - | [[Image:1jsu.gif|left|200px]]<br /> | + | [[Image:1jsu.gif|left|200px]]<br /><applet load="1jsu" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1jsu" size=" | + | |
caption="1jsu, resolution 2.3Å" /> | caption="1jsu, resolution 2.3Å" /> | ||
'''P27(KIP1)/CYCLIN A/CDK2 COMPLEX'''<br /> | '''P27(KIP1)/CYCLIN A/CDK2 COMPLEX'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the human p27Kip1 kinase inhibitory domain bound | + | The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JSU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1JSU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Jeffrey, P | + | [[Category: Jeffrey, P D.]] |
| - | [[Category: Pavletich, N | + | [[Category: Pavletich, N P.]] |
| - | [[Category: Russo, A | + | [[Category: Russo, A A.]] |
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: cdk]] | [[Category: cdk]] | ||
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[[Category: kinase]] | [[Category: kinase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:26:19 2008'' |
Revision as of 11:26, 21 February 2008
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P27(KIP1)/CYCLIN A/CDK2 COMPLEX
Contents |
Overview
The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.
Disease
Known diseases associated with this structure: Multiple endocrine neoplasia, type IV OMIM:[600778]
About this Structure
1JSU is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex., Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP, Nature. 1996 Jul 25;382(6589):325-31. PMID:8684460
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