1klq

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[[Image:1klq.jpg|left|200px]]
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{{Seed}}
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[[Image:1klq.png|left|200px]]
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{{STRUCTURE_1klq| PDB=1klq | SCENE= }}
{{STRUCTURE_1klq| PDB=1klq | SCENE= }}
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'''The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon Binding to Either Mad1 or Cdc20'''
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===The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon Binding to Either Mad1 or Cdc20===
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==Overview==
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Mad2 participates in spindle checkpoint inhibition of APC(Cdc20). We show that RNAi-mediated suppression of Mad1 function in mammalian cells causes loss of Mad2 kinetochore localization and impairment of the spindle checkpoint. Mad1 and Cdc20 contain Mad2 binding motifs that share a common consensus. We have identified a class of Mad2 binding peptides with a similar consensus. Binding of one of these ligands, MBP1, triggers an extensive rearrangement of the tertiary structure of Mad2. Mad2 also undergoes a similar striking structural change upon binding to a Mad1 or Cdc20 binding motif peptide. Our data suggest that, upon checkpoint activation, Mad1 recruits Mad2 to unattached kinetochores and may promote binding of Mad2 to Cdc20.
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The line below this paragraph, {{ABSTRACT_PUBMED_11804586}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11804586 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11804586}}
==About this Structure==
==About this Structure==
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1KLQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLQ OCA].
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1KLQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KLQ OCA].
==Reference==
==Reference==
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[[Category: Mad2 family]]
[[Category: Mad2 family]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:53:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:31:33 2008''

Revision as of 07:31, 2 July 2008

Image:1klq.png

Template:STRUCTURE 1klq

The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon Binding to Either Mad1 or Cdc20

Template:ABSTRACT PUBMED 11804586

About this Structure

1KLQ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20., Luo X, Tang Z, Rizo J, Yu H, Mol Cell. 2002 Jan;9(1):59-71. PMID:11804586

Page seeded by OCA on Wed Jul 2 10:31:33 2008

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