7yun
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human BEND6 BEN domain in complex with methylated DNA== | |
| - | + | <StructureSection load='7yun' size='340' side='right'caption='[[7yun]], [[Resolution|resolution]] 2.13Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7yun]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YUN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yun OCA], [https://pdbe.org/7yun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yun RCSB], [https://www.ebi.ac.uk/pdbsum/7yun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yun ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Min | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/BEND6_HUMAN BEND6_HUMAN] Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214).<ref>PMID:23571214</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Liu K]] | ||
| + | [[Category: Min JR]] | ||
| + | [[Category: Xiao YQ]] | ||
| + | [[Category: Zhang J]] | ||
Revision as of 07:27, 3 May 2023
Crystal structure of human BEND6 BEN domain in complex with methylated DNA
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