1klu

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[[Image:1klu.gif|left|200px]]
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{{Seed}}
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[[Image:1klu.png|left|200px]]
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{{STRUCTURE_1klu| PDB=1klu | SCENE= }}
{{STRUCTURE_1klu| PDB=1klu | SCENE= }}
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'''Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)'''
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===Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)===
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==Overview==
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While most immunotherapies for cancer have focused on eliciting specific CD8+ cytotoxic T lymphocyte killing of tumor cells, a mounting body of evidence suggests that stimulation of anti-tumor CD4+ T cell help may be required for highly effective therapy. Several MHC class II-restricted tumor antigens that specifically activate such CD4+ helper T lymphocytes have now been identified, including one from a melanoma tumor that is caused by a single base-pair mutation in the glycolytic enzyme triosephosphate isomerase. This mutation results in the conversion of a threonine residue to isoleucine within the antigenic epitope, concomitant with a greater than five log-fold increase in stimulation of a CD4+ tumor-infiltrating lymphocyte line. Here, we present the crystal structures of HLA-DR1 in complex with both wild-type and mutant TPI peptide antigens, the first structures of tumor peptide antigen/MHC class II complexes recognized by CD4+ T cells to be reported. These structures show that very minor changes in the binding surface for T cell receptor correspond to the dramatic differences in T cell stimulation. Defining the structural basis by which CD4+ T cell help is invoked in an anti-tumor immune response will likely aid the design of more effective cancer immunotherapies.
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The line below this paragraph, {{ABSTRACT_PUBMED_12051920}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12051920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12051920}}
==About this Structure==
==About this Structure==
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[[Category: Hla-dr1/tpi]]
[[Category: Hla-dr1/tpi]]
[[Category: Human melanoma antigen]]
[[Category: Human melanoma antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:53:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:31:43 2008''

Revision as of 07:31, 2 July 2008

Image:1klu.png

Template:STRUCTURE 1klu

Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)

Template:ABSTRACT PUBMED 12051920

About this Structure

1KLU is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line., Sundberg EJ, Sawicki MW, Southwood S, Andersen PS, Sette A, Mariuzza RA, J Mol Biol. 2002 May 31;319(2):449-61. PMID:12051920

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