8iw1

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'''Unreleased structure'''
 
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The entry 8iw1 is ON HOLD until Paper Publication
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==Cryo-EM structure of the PEA-bound mTAAR9-Golf complex==
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<StructureSection load='8iw1' size='340' side='right'caption='[[8iw1]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors: Sun, J.P., Li, Q., Yang, F., Xu, Y.F., Guo, L.L., Lian, S., Zhang, M.H., Rong, N.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8iw1]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IW1 FirstGlance]. <br>
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Description: Cryo-EM structure of the PEA-bound mTAAR9-Golf complex
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iw1 OCA], [https://pdbe.org/8iw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iw1 RCSB], [https://www.ebi.ac.uk/pdbsum/8iw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iw1 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Sun, J.P]]
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== Disease ==
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[[Category: Zhang, M.H]]
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[https://www.uniprot.org/uniprot/GNAL_HUMAN GNAL_HUMAN] Autosomal dominant focal dystonia, DYT25 type. The disease is caused by variants affecting the gene represented in this entry.
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[[Category: Lian, S]]
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== Function ==
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[[Category: Xu, Y.F]]
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> [https://www.uniprot.org/uniprot/GNAL_HUMAN GNAL_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
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[[Category: Li, Q]]
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== References ==
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[[Category: Yang, F]]
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<references/>
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[[Category: Guo, L.L]]
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__TOC__
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[[Category: Rong, N.K]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Synthetic construct]]
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[[Category: Guo LL]]
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[[Category: Li Q]]
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[[Category: Lian S]]
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[[Category: Rong NK]]
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[[Category: Sun JP]]
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[[Category: Xu YF]]
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[[Category: Yang F]]
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[[Category: Zhang MH]]

Revision as of 05:46, 31 May 2023

Cryo-EM structure of the PEA-bound mTAAR9-Golf complex

PDB ID 8iw1

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