8oig
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Staphopain C from Staphylococcus aureus== | |
| + | <StructureSection load='8oig' size='340' side='right'caption='[[8oig]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8oig]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OIG FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oig OCA], [https://pdbe.org/8oig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oig RCSB], [https://www.ebi.ac.uk/pdbsum/8oig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oig ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8RJP3_STAAU Q8RJP3_STAAU] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Staphylococcus aureus is a common opportunistic pathogen of humans and livestock that causes a wide variety of infections. The success of S. aureus as a pathogen depends on the production of an array of virulence factors including cysteine proteases (staphopains)-major secreted proteases of certain strains of the bacterium. Here, we report the three-dimensional structure of staphopain C (ScpA2) of S. aureus, which shows the typical papain-like fold and uncovers a detailed molecular description of the active site. Because the protein is involved in the pathogenesis of a chicken disease, our work provides the foundation for inhibitor design and potential antimicrobial strategies against this pathogen. | ||
| - | + | Crystal Structure of Staphopain C from Staphylococcus aureus.,Magoch M, McEwen AG, Napolitano V, Wladyka B, Dubin G Molecules. 2023 May 29;28(11):4407. doi: 10.3390/molecules28114407. PMID:37298883<ref>PMID:37298883</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8oig" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Staphylococcus aureus]] | ||
| + | [[Category: Dubin G]] | ||
| + | [[Category: Magoch M]] | ||
| + | [[Category: McEwen AG]] | ||
| + | [[Category: Napolitano V]] | ||
| + | [[Category: Wladyka B]] | ||
Revision as of 09:42, 21 June 2023
Crystal Structure of Staphopain C from Staphylococcus aureus
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