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1kmq

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[[Image:1kmq.gif|left|200px]]
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{{STRUCTURE_1kmq| PDB=1kmq | SCENE= }}
{{STRUCTURE_1kmq| PDB=1kmq | SCENE= }}
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'''Crystal Structure of a Constitutively Activated RhoA Mutant (Q63L)'''
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===Crystal Structure of a Constitutively Activated RhoA Mutant (Q63L)===
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==Overview==
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Mutants of the small G protein RhoA that are deficient in GTPase activity and thereby exhibit constitutive molecular signaling activity are commonly used to discover its cellular functions. In particular, two such mutants, Gly14--&gt;Val (G14V) and Gln63--&gt;Leu (Q63L), are often used interchangeably for such studies. However, while their in vitro rates of GTP hydrolysis are very similar, differences are observed in their other functional properties. The structure of G14V-RhoA is known; in order to assess whether structural variations are responsible for functional differences, the crystal structure of a Q63L-RhoA bound to the GTP-analog 5'-guanylylimidodiphosphate (GMPPNP) was determined at 1.5 A resolution. Overall, the structure is very similar to that of G14V-RhoA, but the significantly higher resolution data permit an improved basis for structural analysis and comparison. The data support the notion that differences observed between the mutants in vivo are likely to arise from altered affinities for RhoGDI and not from direct structural differences.
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The line below this paragraph, {{ABSTRACT_PUBMED_12777804}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12777804 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12777804}}
==About this Structure==
==About this Structure==
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[[Category: Gtp-analog]]
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[[Category: Gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:55:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:34:00 2008''

Revision as of 07:34, 2 July 2008

Image:1kmq.png

Template:STRUCTURE 1kmq

Crystal Structure of a Constitutively Activated RhoA Mutant (Q63L)

Template:ABSTRACT PUBMED 12777804

About this Structure

1KMQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution., Longenecker K, Read P, Lin SK, Somlyo AP, Nakamoto RK, Derewenda ZS, Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):876-80. Epub 2003, Apr 25. PMID:12777804

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