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1knx

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{{STRUCTURE_1knx| PDB=1knx | SCENE= }}
{{STRUCTURE_1knx| PDB=1knx | SCENE= }}
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'''HPr kinase/phosphatase from Mycoplasma pneumoniae'''
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===HPr kinase/phosphatase from Mycoplasma pneumoniae===
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==Overview==
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HPr kinase/phosphatase (HPrK/P) modifies serine 46 of histidine-containing protein (HPr), the phosphorylation state of which is the control point of carbon catabolite repression in low G+C Gram-positive bacteria. To understand the structural mechanism by which HPrK/P carries out its dual, competing activities we determined the structure of full length HPrK/P from Mycoplasma pneumoniae (PD8 ID, 1KNX) to 2.5A resolution. The enzyme forms a homo-hexamer with each subunit containing two domains connected by a short loop. The C-terminal domain contains the well-described P-loop (Walker A box) ATP binding motif and takes a fold similar to phosphoenolpyruvate carboxykinase (PEPCK) from Escherichia coli as recently described in other HPrK/P structures. As expected, the C-terminal domain is very similar to the C-terminal fragment of Lactobacillus casei HPrK/P and the C-terminal domain of Staphylococcus xylosus HPrK/P; the N-terminal domain is very similar to the N-terminal domain of S.xylosus HPrK/P. Unexpectedly, the N-terminal domain resembles UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase (MurE), yet the function of this domain is unclear. We discuss these observations as well as the structural significance of mutations in the P-loop and HPrK/P family sequence motif.
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{{ABSTRACT_PUBMED_12589763}}
==About this Structure==
==About this Structure==
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[[Category: Phosphatase]]
[[Category: Phosphatase]]
[[Category: Walker a box]]
[[Category: Walker a box]]
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Revision as of 07:37, 2 July 2008

Image:1knx.png

Template:STRUCTURE 1knx

HPr kinase/phosphatase from Mycoplasma pneumoniae

Template:ABSTRACT PUBMED 12589763

About this Structure

1KNX is a Single protein structure of sequence from Mycoplasma pneumoniae. Full crystallographic information is available from OCA.

Reference

Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae., Allen GS, Steinhauer K, Hillen W, Stulke J, Brennan RG, J Mol Biol. 2003 Feb 28;326(4):1203-17. PMID:12589763

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