1knz

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[[Image:1knz.gif|left|200px]]
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{{STRUCTURE_1knz| PDB=1knz | SCENE= }}
{{STRUCTURE_1knz| PDB=1knz | SCENE= }}
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'''Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer'''
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===Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer===
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==Overview==
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Rotaviruses, the cause of life-threatening diarrhea in humans and cattle, utilize a functional homolog of poly(A) binding protein (PABP) known as nonstructural protein 3 (NSP3) for translation of viral mRNAs. NSP3 binds to viral mRNA 3' consensus sequences and circularizes the mRNA via interactions with eIF4G. The X-ray structure of the NSP3 RNA binding domain bound to a rotaviral mRNA 3' end has been determined. NSP3 is a novel, heart-shaped homodimer with a medial RNA binding cleft. The homodimer is asymmetric, and contains two similar N-terminal segments plus two structurally different C-terminal segments that intertwine to create a tunnel enveloping the mRNA 3' end. Biophysical studies demonstrate high affinity binding leading to increased thermal stability and slow dissociation kinetics, consistent with NSP3 function.
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(as it appears on PubMed at http://www.pubmed.gov), where 11792322 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11792322}}
==About this Structure==
==About this Structure==
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[[Category: Rajashankar, K R.]]
[[Category: Rajashankar, K R.]]
[[Category: Protein-ssrna complex]]
[[Category: Protein-ssrna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:57:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:37:13 2008''

Revision as of 07:37, 2 July 2008

Image:1knz.png

Template:STRUCTURE 1knz

Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer

Template:ABSTRACT PUBMED 11792322

About this Structure

1KNZ is a Single protein structure of sequence from Simian rotavirus a/sa11. Full crystallographic information is available from OCA.

Reference

Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer., Deo RC, Groft CM, Rajashankar KR, Burley SK, Cell. 2002 Jan 11;108(1):71-81. PMID:11792322

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