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1ko9

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{{STRUCTURE_1ko9| PDB=1ko9 | SCENE= }}
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'''Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1'''
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===Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1===
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==Overview==
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Both 8oxo-guanine and formamidopyrimidines are major products of oxidative DNA damage that can result in the fixation of transversion mutations following replication if left unrepaired. These lesions are targeted by the N-DNA glycosylase hOgg1, which catalyses excision of the aberrant base followed by cleavage of the phosphate backbone directly 5' to the resultant abasic site in a context, dependent manner. We present the crystal structure of native hOgg1 refined to 2.15 A resolution that reveals a number of highly significant conformational changes on association with DNA that are clearly required for substrate recognition and specificity. Changes of this magnitude appear to be unique to hOgg1 and have not been observed in any of the DNA-glycosylase structures analysed to date where both native and DNA-bound forms are available. It has been possible to identify a mechanism whereby the catalytic residue Lys 249 is "primed" for nucleophilic attack of the N-glycosidic bond.
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{{ABSTRACT_PUBMED_11902834}}
==Disease==
==Disease==
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[[Category: Seeberg, E.]]
[[Category: Seeberg, E.]]
[[Category: Helix-hairpin-helix dna-glycosylase]]
[[Category: Helix-hairpin-helix dna-glycosylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:58:31 2008''
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Revision as of 07:38, 2 July 2008

Image:1ko9.png

Template:STRUCTURE 1ko9

Contents

Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1

Template:ABSTRACT PUBMED 11902834

Disease

Known disease associated with this structure: Renal cell carcinoma, clear cell, somatic OMIM:[601982]

About this Structure

1KO9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase., Bjoras M, Seeberg E, Luna L, Pearl LH, Barrett TE, J Mol Biol. 2002 Mar 22;317(2):171-7. PMID:11902834

Page seeded by OCA on Wed Jul 2 10:38:19 2008

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