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1koe

From Proteopedia

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{{STRUCTURE_1koe| PDB=1koe | SCENE= }}
{{STRUCTURE_1koe| PDB=1koe | SCENE= }}
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'''ENDOSTATIN'''
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===ENDOSTATIN===
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==Overview==
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A number of extracellular proteins contain cryptic inhibitors of angiogenesis. Endostatin is a 20 kDa C-terminal proteolytic fragment of collagen XVIII that potently inhibits endothelial cell proliferation and angiogenesis. Therapy of experimental cancer with endostatin leads to tumour dormancy and does not induce resistance. We have expressed recombinant mouse endostatin and determined its crystal structure at 1.5 A resolution. The structure reveals a compact fold distantly related to the C-type lectin carbohydrate recognition domain and the hyaluronan-binding Link module. The high affinity of endostatin for heparin is explained by the presence of an extensive basic patch formed by 11 arginine residues. Endostatin may inhibit angiogenesis by binding to the heparan sulphate proteoglycans involved in growth factor signalling.
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{{ABSTRACT_PUBMED_9501087}}
==About this Structure==
==About this Structure==
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[[Category: Heparin-binding domain]]
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[[Category: Non-collageneous domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:58:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:38:46 2008''

Revision as of 07:38, 2 July 2008

Image:1koe.png

Template:STRUCTURE 1koe

ENDOSTATIN

Template:ABSTRACT PUBMED 9501087

About this Structure

1KOE is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution., Hohenester E, Sasaki T, Olsen BR, Timpl R, EMBO J. 1998 Mar 16;17(6):1656-64. PMID:9501087

Page seeded by OCA on Wed Jul 2 10:38:46 2008

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