8ov6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Ternary structure of bivalent glue degrader compound 1 bound to BRD4 and DCAF16:DDB1deltaBPB== | |
| - | + | <StructureSection load='8ov6' size='340' side='right'caption='[[8ov6]], [[Resolution|resolution]] 3.77Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ov6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OV6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U79:methyl+2-[(9~{S})-7-[4-[4-[[4-[(3-cyano-4-methyl-1~{H}-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoate'>U79</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ov6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ov6 OCA], [https://pdbe.org/8ov6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ov6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ov6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ov6 ProSAT]</span></td></tr> |
| - | [[Category: Ciulli | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/DCA16_HUMAN DCA16_HUMAN] Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.<ref>PMID:16949367</ref> <ref>PMID:31209349</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ciulli A]] | ||
| + | [[Category: Cowan AD]] | ||
| + | [[Category: Nakasone MA]] | ||
| + | [[Category: Sundaramoorthy R]] | ||
Revision as of 07:03, 18 May 2023
Ternary structure of bivalent glue degrader compound 1 bound to BRD4 and DCAF16:DDB1deltaBPB
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