1kpz

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{{STRUCTURE_1kpz| PDB=1kpz | SCENE= }}
{{STRUCTURE_1kpz| PDB=1kpz | SCENE= }}
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'''PEMV-1 P1-P2 Frameshifting Pseudoknot Regularized Average Structure'''
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===PEMV-1 P1-P2 Frameshifting Pseudoknot Regularized Average Structure===
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==Overview==
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A hairpin-type messenger RNA pseudoknot from pea enation mosaic virus RNA1 (PEMV-1) regulates the efficiency of programmed -1 ribosomal frameshifting. The solution structure and 15N relaxation rates reveal that the PEMV-1 pseudoknot is a compact-folded structure composed almost entirely of RNA triple helix. A three nucleotide reverse turn in loop 1 positions a protonated cytidine, C(10), in the correct orientation to form an A((n-1)).C(+).G-C(n) major groove base quadruple, like that found in the beet western yellows virus pseudoknot and the hepatitis delta virus ribozyme, despite distinct structural contexts. A novel loop 2-loop 1 A.U Hoogsteen base-pair stacks on the C(10)(+).G(28) base-pair of the A(12).C(10)(+).G(28)-C(13) quadruple and forms a wedge between the pseudoknot stems stabilizing a bent and over-rotated global conformation. Substitution of key nucleotides that stabilize the unique conformation of the PEMV-1 pseudoknot greatly reduces ribosomal frameshifting efficacy.
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(as it appears on PubMed at http://www.pubmed.gov), where 12225754 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12225754}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPZ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KPZ OCA].
==Reference==
==Reference==
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[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: Triple helix]]
[[Category: Triple helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:01:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:44:31 2008''

Revision as of 07:44, 2 July 2008

Image:1kpz.png

Template:STRUCTURE 1kpz

PEMV-1 P1-P2 Frameshifting Pseudoknot Regularized Average Structure

Template:ABSTRACT PUBMED 12225754

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of a luteoviral P1-P2 frameshifting mRNA pseudoknot., Nixon PL, Rangan A, Kim YG, Rich A, Hoffman DW, Hennig M, Giedroc DP, J Mol Biol. 2002 Sep 20;322(3):621-33. PMID:12225754

Page seeded by OCA on Wed Jul 2 10:44:31 2008

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