1kq9

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{{STRUCTURE_1kq9| PDB=1kq9 | SCENE= }}
{{STRUCTURE_1kq9| PDB=1kq9 | SCENE= }}
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'''Human methionine aminopeptidase type II in complex with L-methionine'''
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===Human methionine aminopeptidase type II in complex with L-methionine===
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==Overview==
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Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes establishes the basis of enantiomer discrimination and provides some considerations for the design of selective MetAP-2 inhibitors.
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{{ABSTRACT_PUBMED_16540317}}
==About this Structure==
==About this Structure==
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[[Category: Widom, J.]]
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Revision as of 07:45, 2 July 2008

Template:STRUCTURE 1kq9

Human methionine aminopeptidase type II in complex with L-methionine

Template:ABSTRACT PUBMED 16540317

About this Structure

1KQ9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human methionine aminopeptidase type 2 in complex with L- and D-methionine., Nonato MC, Widom J, Clardy J, Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. PMID:16540317

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