Journal:Proteins:3

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An example of an Orphan protein that is predicted by all three algorithms to be an IDP is the wheat protein TaFROG. It contains 130 amino acids localized in the nucleus. It confers resistance on wheat to the mycotoxigenic fungus, ''Fusarium graminearum''<ref name="TaFROG">PMID:26508775</ref>.
An example of an Orphan protein that is predicted by all three algorithms to be an IDP is the wheat protein TaFROG. It contains 130 amino acids localized in the nucleus. It confers resistance on wheat to the mycotoxigenic fungus, ''Fusarium graminearum''<ref name="TaFROG">PMID:26508775</ref>.
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Although the pLDDT<ref name="pLDDT">PMID:23986568</ref> scores for most of the ''Never Born'' and ''Newly Born'' proteins are low, the overall conformation of the 3D structures that they predict appear to give very consistent correlations of a compact folded protein versus an IDP. Thus, the approach to using recently developed AI/Deep Learning tools to indicate the overall shape of these proteins is useful.
Although the pLDDT<ref name="pLDDT">PMID:23986568</ref> scores for most of the ''Never Born'' and ''Newly Born'' proteins are low, the overall conformation of the 3D structures that they predict appear to give very consistent correlations of a compact folded protein versus an IDP. Thus, the approach to using recently developed AI/Deep Learning tools to indicate the overall shape of these proteins is useful.

Revision as of 16:52, 8 May 2023

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Proteopedia Page Contributors and Editors (what is this?)

Joel L. Sussman, Jaime Prilusky

This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
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