8p0s

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m (Protected "8p0s" [edit=sysop:move=sysop])
Current revision (09:42, 21 June 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8p0s is ON HOLD
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==Crystal structure HR1 domain of Rho-associated coiled-coil protein kinases (ROCK-HR1)==
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<StructureSection load='8p0s' size='340' side='right'caption='[[8p0s]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Dubey, B.N., Dvorsky, R., Gremer, L., Vetter, I.R., Schmitt, L., Groth, G., Ahmadian, M.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8p0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P0S FirstGlance]. <br>
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Description: Crystal structure HR1 domain of Rho-associated coiled-coil protein kinases (ROCK-HR1)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p0s OCA], [https://pdbe.org/8p0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p0s RCSB], [https://www.ebi.ac.uk/pdbsum/8p0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p0s ProSAT]</span></td></tr>
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[[Category: Dubey, B.N]]
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</table>
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[[Category: Vetter, I.R]]
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== Function ==
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[[Category: Dvorsky, R]]
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[https://www.uniprot.org/uniprot/ROCK1_HUMAN ROCK1_HUMAN] Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.<ref>PMID:8617235</ref> <ref>PMID:9722579</ref> <ref>PMID:10436159</ref> <ref>PMID:10652353</ref> <ref>PMID:11018042</ref> <ref>PMID:11283607</ref> <ref>PMID:17158456</ref> <ref>PMID:18694941</ref> <ref>PMID:18573880</ref> <ref>PMID:19036714</ref> <ref>PMID:19181962</ref> <ref>PMID:19131646</ref> <ref>PMID:19997641</ref> <ref>PMID:21072057</ref>
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[[Category: Schmitt, L]]
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== References ==
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[[Category: Ahmadian, M.R]]
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<references/>
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[[Category: Gremer, L]]
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__TOC__
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[[Category: Groth, G]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Ahmadian MR]]
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[[Category: Dubey BN]]
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[[Category: Dvorsky R]]
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[[Category: Gremer L]]
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[[Category: Groth G]]
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[[Category: Schmitt L]]
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[[Category: Vetter IR]]

Current revision

Crystal structure HR1 domain of Rho-associated coiled-coil protein kinases (ROCK-HR1)

PDB ID 8p0s

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