1ku5

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{{STRUCTURE_1ku5| PDB=1ku5 | SCENE= }}
{{STRUCTURE_1ku5| PDB=1ku5 | SCENE= }}
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'''Crystal Structure of recombinant histone HPhA from hyperthermophilic archaeon Pyrococcus horikoshii OT3'''
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===Crystal Structure of recombinant histone HPhA from hyperthermophilic archaeon Pyrococcus horikoshii OT3===
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==Overview==
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The histone protein HPhA from the hyperthermophilic archaeon Pyrococcus horikoshii, shows hyperthermostability, as required for optimal growth of the organism at 95 degrees C. The structure of recombinant P.horikoshii HPhA has been determined to 2.3A resolution by molecular replacement, and refined to R(work) and R(free) values of 20.7% and 27.3%, respectively. The HPhA monomer structure is characterized by the histone fold and assembles into a homodimer like other archaeal histones. There are four anions found in the dimer structure, giving rise to clues as to where DNA might bind. A detailed comparison of four known structures of archaeal histones, which evolve and exist under different temperatures, shows that the thermophilic archaeal histone HPhA has a larger hydrophobic contact area, an increased number of hydrogen bonds and a reduced solvent-accessible area. We also observe a unique network of tyrosine residues located at the crossover point of the two HPhA monomers, which locks them together and stabilizes the dimer. These factors together account for the increased thermal stability.
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(as it appears on PubMed at http://www.pubmed.gov), where 12527306 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12527306}}
==About this Structure==
==About this Structure==
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[[Category: Sun, F.]]
[[Category: Sun, F.]]
[[Category: Histone fold]]
[[Category: Histone fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:10:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:00:43 2008''

Revision as of 08:00, 2 July 2008

Image:1ku5.png

Template:STRUCTURE 1ku5

Crystal Structure of recombinant histone HPhA from hyperthermophilic archaeon Pyrococcus horikoshii OT3

Template:ABSTRACT PUBMED 12527306

About this Structure

1KU5 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Structure based hyperthermostability of archaeal histone HPhA from Pyrococcus horikoshii., Li T, Sun F, Ji X, Feng Y, Rao Z, J Mol Biol. 2003 Jan 31;325(5):1031-7. PMID:12527306

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