1k78
From Proteopedia
(New page: 200px<br /> <applet load="1k78" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k78, resolution 2.25Å" /> '''Pax5(1-149)+Ets-1(3...) |
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| - | [[Image:1k78.gif|left|200px]]<br /> | + | [[Image:1k78.gif|left|200px]]<br /><applet load="1k78" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1k78" size=" | + | |
caption="1k78, resolution 2.25Å" /> | caption="1k78, resolution 2.25Å" /> | ||
'''Pax5(1-149)+Ets-1(331-440)+DNA'''<br /> | '''Pax5(1-149)+Ets-1(331-440)+DNA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Pax5 regulates the B cell-specific expression of the mb-1 gene together | + | Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K78 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1K78 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K78 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Garvie, C | + | [[Category: Garvie, C W.]] |
[[Category: Hagman, J.]] | [[Category: Hagman, J.]] | ||
[[Category: Wolberger, C.]] | [[Category: Wolberger, C.]] | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:30:53 2008'' |
Revision as of 11:30, 21 February 2008
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Pax5(1-149)+Ets-1(331-440)+DNA
Contents |
Overview
Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription.
Disease
Known disease associated with this structure: Lymphoplasmacytoid lymphoma OMIM:[167414]
About this Structure
1K78 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502
Page seeded by OCA on Thu Feb 21 13:30:53 2008
