Histone deacetylase 3D structures
From Proteopedia
(Difference between revisions)
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**[[8bpa]], [[8bpb]], [[8c60]] – hHDAC2 + SIN3B + PF1 – Cryo EM<br /> | **[[8bpa]], [[8bpb]], [[8c60]] – hHDAC2 + SIN3B + PF1 – Cryo EM<br /> | ||
**[[8bpc]] – hHDAC2 + SIN3B + PF1 + SAHA – Cryo EM<br /> | **[[8bpc]] – hHDAC2 + SIN3B + PF1 + SAHA – Cryo EM<br /> | ||
| - | **[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]], [[7js8]], [[7kbh]], [[7kbg]], [[7ltg]], [[7ltk]], [[7ltl]], [[7mot]], [[7mox]], [[7moy]] – hHDAC2 core domain + inhibitor<br /> | + | **[[8bpa]], [[8bpb]], [[8c60]] – hHDAC2 + SIN3B + PF1 – Cryo EM<br /> |
| + | **[[8bpc]] – hHDAC2 + SIN3B + PF1 + SAHA – Cryo EM<br /> | ||
| + | **[[4ly1]], [[5iwg]], [[5ix0]], [[6wbz]], [[6wbw]], [[6xdm]], [[6xeb]], [[6xec]], [[7js8]], [[7kbh]], [[7kbg]], [[7ltg]], [[7ltk]], [[7ltl]], [[7mot]], [[7mox]], [[7moy]], [[7zzo]], [[7zzp]], [[7zzr]], [[7zzs]], [[7zzt]], [[7zzv]], [[7zzw]], [[8a0b]] – hHDAC2 core domain + inhibitor<br /> | ||
**[[6whn]], [[6who]], [[6whq]], [[6whz]], [[6wi3]], [[7mos]], [[7moz]] – hHDAC2 core domain + peptide macrocycle<br /> | **[[6whn]], [[6who]], [[6whq]], [[6whz]], [[6wi3]], [[7mos]], [[7moz]] – hHDAC2 core domain + peptide macrocycle<br /> | ||
| + | **[[7vrr]] – AtHDAC2a residues 1-95 – ''Arabidopsis thaliana''<br /> | ||
| + | **[[7vmf]], [[7vmh]] – AtHDAC2d residues 1-95 <br /> | ||
| + | **[[7vmi]] – AtHDAC2c residues 1-95 <br /> | ||
*HDAC3 | *HDAC3 | ||
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**[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br /> | **[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br /> | ||
**[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br /> | **[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br /> | ||
| - | **[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]], [[6tld]], [[7p3s]] – SmHDAC8 + inhibitor<br /> | + | **[[4bz7]], [[4bz8]], [[4bz9]], [[4cqf]], [[6hsz]], [[6ht8]], [[6htg]], [[6hth]], [[6hti]], [[6htt]], [[6htz]], [[6hu0]], [[6hu1]], [[6hu2]], [[6hu3]], [[6hsh]], [[6hrq]], [[6hqy]], [[6tld]], [[7p2s]], [[7p2t]], [[7p2u]], [[7p2v]], [[7p3s]], [[7poz]] – SmHDAC8 + inhibitor<br /> |
**[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor<br /> | **[[6hsk]], [[6hsf]], [[6hsg]] – SmHDAC8 (mutant) + inhibitor<br /> | ||
**[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative<br /> | **[[4bz6]], [[6gxw]], [[6gxu]], [[6gxa]], [[6gx3]], [[6fu1]] – SmHDAC8 + SAHA derivative<br /> | ||
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*HDAC10 or polyamine deacetylase 10 | *HDAC10 or polyamine deacetylase 10 | ||
| - | **[[7kuv]] – zHDAC10 - zebrafish<br /> | + | **[[5td7]], [[7kuv]] – zHDAC10 - zebrafish<br /> |
| - | **[[6ufn]], [[6ufo]], [[6uhu]], [[6uhv]], [[6uii]], [[6uij]], [[6uil]], [[6uim]], [[6wbq]], [[6wdv]], [[6wdw]], [[6wdx]], [[6wdy]] – zHDAC10 + inhibitor<br /> | + | **[[6ufn]], [[6ufo]], [[6uhu]], [[6uhv]], [[6uii]], [[6uij]], [[6uil]], [[6uim]], [[6wbq]], [[6wdv]], [[6wdw]], [[6wdx]], [[6wdy]], [[7sgg]], [[7sgi]], [[7sgj]], [[7sgk]], [[7u3m]], [[7u59]], [[7u69]], [[7u6a]], [[7u6b]] – zHDAC10 + inhibitor<br /> |
**[[6vnq]], [[7kuq]], [[7kur]], [[7kus]], [[7kut]] – zHDAC10 (mutant) + inhibitor <br /> | **[[6vnq]], [[7kuq]], [[7kur]], [[7kus]], [[7kut]] – zHDAC10 (mutant) + inhibitor <br /> | ||
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**[[2ld7]] – hHDAC subunit SAP30 +SIN3A PAH 3 domain – NMR<br /> | **[[2ld7]] – hHDAC subunit SAP30 +SIN3A PAH 3 domain – NMR<br /> | ||
**[[5ikk]] – HDAC CLR3 – fission yeast<br /> | **[[5ikk]] – HDAC CLR3 – fission yeast<br /> | ||
| + | **[[7q1b]], [[7q1c]] – HDAC DAC2 + inhibitor – ''Trypanosoma cruzi''<br /> | ||
*'''HDAC class IIB''' | *'''HDAC class IIB''' | ||
| - | *HDAC6 | + | *HDAC6; ; Domains – catalytic 2 288-646; CD1 – 40-440; CD2 440-798; zinc finger 1109-1213 |
**[[3c5k]] – hHDAC6 zinc finger domain<br /> | **[[3c5k]] – hHDAC6 zinc finger domain<br /> | ||
**[[3gv4]] - hHDAC6 zinc finger domain + ubiquitin peptide<br /> | **[[3gv4]] - hHDAC6 zinc finger domain + ubiquitin peptide<br /> | ||
**[[3phd]] - hHDAC6 + polyubiquitin<br /> | **[[3phd]] - hHDAC6 + polyubiquitin<br /> | ||
| - | **[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]] – hHDAC6 zinc finger + inhibitor<br /> | + | **[[5kh3]], [[5kh7]], [[5kh9]], [[5b8d]], [[6ce6]], [[6ce8]], [[6cea]], [[6cec]], [[6ced]], [[6cee]], [[6cef]], [[5wpb]], [[5wbn]], [[8g43]], [[8g44]], [[8g45]] – hHDAC6 zinc finger + inhibitor<br /> |
| + | **[[7qno]] – zHDAC6 CD1+CD2 domain <br /> | ||
**[[5eem]] – zHDAC6 catalytic domain<br /> | **[[5eem]] – zHDAC6 catalytic domain<br /> | ||
| - | **[[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]], [[6pye]], [[6pzo]], [[6pzr]], [[6pzs]], [[6pzu]], [[6q0z]], [[6r0k]], [[6tcy]], [[6thv]], [[6uo2]], [[6uo3]], [[6uo5]], [[6uo7]], [[6v79]], [[6v7a]], [[6vnr]], [[6zw1]], [[7jom]] – zHDAC6 catalytic domain + inhibitor <br /> | + | **[[5edu]], [[6cgp]], [[5wgm]], [[5wgl]], [[5wgi]], [[5wgk]], [[5g0j]], [[5g0i]], [[5g0h]], [[5g0g]], [[5g0f]], [[5efh]], [[5efg]], [[5efb]], [[5ef7]], [[5ef8]], [[5een]], [[5eek]], [[5eef]], [[6mr5]], [[6dvo]], [[6dvn]], [[6dvm]], [[6dvl]], [[6cw8]], [[6pye]], [[6pzo]], [[6pzr]], [[6pzs]], [[6pzu]], [[6q0z]], [[6r0k]], [[6tcy]], [[6thv]], [[6uo2]], [[6uo3]], [[6uo5]], [[6uo7]], [[6v79]], [[6v7a]], [[6vnr]], [[6zw1]], [[7jom]], [[7o2p]], [[7o2r]], [[7u8z]], [[7uk2]], [[8d98]], [[8d99]], [[8d9a]], [[8d9b]], [[8d9c]] – zHDAC6 catalytic domain 2 + inhibitor <br /> |
**[[6uo4]], [[6uo7]], [[6uob]], [[6uoc]], [[6wyo]] – zHDAC6 catalytic domain (mutant) + inhibitor <br /> | **[[6uo4]], [[6uo7]], [[6uob]], [[6uoc]], [[6wyo]] – zHDAC6 catalytic domain (mutant) + inhibitor <br /> | ||
**[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative<br /> | **[[5eei]], [[6css]], [[6csr]], [[6csq]], [[6csp]], [[5w5k]] – zHDAC6 catalytic domain + SAHA derivative<br /> | ||
**[[6wyp]], [[6wyq]] – zHDAC6 catalytic domain (mutant) + SAHA derivative<br /> | **[[6wyp]], [[6wyq]] – zHDAC6 catalytic domain (mutant) + SAHA derivative<br /> | ||
| - | **[[6wsj]] – zHDAC6 catalytic domain + peptide <br /> | + | **[[6wsj]], [[8eqi]] – zHDAC6 catalytic domain 2 + peptide <br /> |
| + | **[[5efj]] – zHDAC6 catalytic domain 2 + HC toxin <br /> | ||
**[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide <br /> | **[[5efn]], [[5efk]], [[53fj]] – zHDAC6 catalytic domain (mutant) + peptide <br /> | ||
| + | **[[8a8z]] – zHDAC6 CD2 domain 440-798 + inhibitor <br /> | ||
*HDAC15 | *HDAC15 | ||
| - | **[[6j6t]] – | + | **[[6j6t]] – AtHDAC15 HD domain <br /> |
*'''HDAC class III''' | *'''HDAC class III''' | ||
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**[[5iqz]] – hSIRT7 N-terminal<br /> | **[[5iqz]] – hSIRT7 N-terminal<br /> | ||
| + | |||
| + | *HDAC-like | ||
| + | |||
| + | **[[1zz0]], [[5g1b]] – AbHDAH – ''Alcalifenaceae bacterium''<br /> | ||
| + | **[[1zz3]], [[2gh6]], [[2vcg]], [[5g1a]], [[5g1c]], [[5g3w]] – AbHDAH + inhibitor <br /> | ||
| + | **[[5g17]] – AbHDAH (mutant) + inhibitor <br /> | ||
| + | **[[1zz1]] – AbHDAH + SAHA <br /> | ||
| + | **[[5g0y]] – PaHDAH – ''Pseudomonas aeruginosa''<br /> | ||
| + | **[[5li3]] – PaHDAH + inhibitor <br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:23, 22 May 2023
3D Structures of histone deacetylase
Updated on 22-May-2023
