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Hydroxylases 3D structures

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*Phenylalanine hydroxylase
+
 
 +
*Phenylalanine hydroxylase (cofactor tetrahydrobiopterin)
**[[6n1k]] – hPAH (mutant) – human<br />
**[[6n1k]] – hPAH (mutant) – human<br />
Line 16: Line 17:
**[[1tg2]], [[1lrm]] - hPAH catalytic domain (mutant) + cofactor<br />
**[[1tg2]], [[1lrm]] - hPAH catalytic domain (mutant) + cofactor<br />
**[[1mmk]], [[1mmt]], [[1kw0]] - hPAH catalytic domain + cofactor + substrate<br />
**[[1mmk]], [[1mmt]], [[1kw0]] - hPAH catalytic domain + cofactor + substrate<br />
-
**[[4anp]] - hPAH catalytic domain + pyrimidine derivative<br />
+
**[[4anp]] - hPAH catalytic domain + pyrimidine derivative
**[[5fii]], [[5fgi]] - hPAH residues 19-118 + phenylalanine<br />
**[[5fii]], [[5fgi]] - hPAH residues 19-118 + phenylalanine<br />
**[[1phz]], [[2phm]], [[5den]], [[5fgj]], [[5den]] – rPAH - rat<br />
**[[1phz]], [[2phm]], [[5den]], [[5fgj]], [[5den]] – rPAH - rat<br />
Line 25: Line 26:
**[[2v27]], [[2v28]] – PAH – ''Colwellia psychrerythraea''<br />
**[[2v27]], [[2v28]] – PAH – ''Colwellia psychrerythraea''<br />
**[[1ltu]], [[1ltv]] – CvPAH – ''Chromobacterium violaceum''<br />
**[[1ltu]], [[1ltv]] – CvPAH – ''Chromobacterium violaceum''<br />
-
**[[1phz]], [[2phm]], [[5fgj]], [[5den]] – rPAH - rat<br />
 
-
**[[5egq]] - rPAH (mutant) <br />
 
**[[4bpt]] – PAH –'' Legionella pneumophila''<br />
**[[4bpt]] – PAH –'' Legionella pneumophila''<br />
**[[1ltz]] - CvPAH + cofactor<br />
**[[1ltz]] - CvPAH + cofactor<br />
Line 34: Line 33:
**[[4jpx]] - CvPAH (mutant) + Co + phenylalanine<br />
**[[4jpx]] - CvPAH (mutant) + Co + phenylalanine<br />
**[[4jpy]] - CvPAH + Fe + phenylalanine<br />
**[[4jpy]] - CvPAH + Fe + phenylalanine<br />
 +
**[[7vgm]] - PAH + Fe – Bacillus cereus<br />
-
*Tyrosine hydroxylase
+
*Tyrosine hydroxylase (cofactor tetrahydrobiopterin)
-
**[[2xsn]] – hTH catalytic domain <br />
+
**[[7a2g]] – hTH – Cryo EM<br />
-
**[[2toh]], [[1toh]] – TH catalytic and tetramerization domains - rat<br />
+
**[[6zn2]], [[6zvp]], [[7pim]] – hTH + dopamine – Cryo EM<br />
-
**[[7kqr]], [[7kqs]], [[7kqt]], [[7kqu]] – TH + heme + Tyr derivative – ''Streptomyces sclerotialus'' <br />
+
**[[2xsn]], [[6zzu]] – hTH catalytic domain 193-528<br />
 +
**[2toh]], [[1toh]] – rTH catalytic and tetramerization domains 160-498 – rat
 +
**[[2mda]] – rTH regulatory domain 65-159 – NMR<br />
 +
**[[7kqr]], [[7kqs]], [[7kqt]], [[7kqu]] – TH + heme + Tyr derivative – Streptomyces sclerotialus <br />
*Tryptophan hydroxylase
*Tryptophan hydroxylase
-
**[[3hf8]], [[3hfb]], [[3hf6]], [[5tpg]], [[5l01]], [[5j6d]] – hTPH 1 catalytic domain+ inhibitor + Fe <br />
+
**[[7wiy]] – hTPH 2 + Fe – Cryo EM<br />
 +
**[[3hf8]], [[3hfb]], [[3hf6]], [[5tpg]], [[5l01]], [[5j6d]], [[7zig]], [[7zih]], [[7zif]], [[7zii]], [[7zij]], [[7zik]] – hTPH 1 catalytic domain 105-401 + inhibitor + Fe <br />
**[[1mlw]] – hTPH catalytic domain+ biopterin + Fe<br />
**[[1mlw]] – hTPH catalytic domain+ biopterin + Fe<br />
**[[4v06]] - hTPH 2 catalytic domain + Fe<br />
**[[4v06]] - hTPH 2 catalytic domain + Fe<br />
 +
**[[7qri]] - hTPH 2 regulatory domain 48-145 + Phe - NMR<br />
**[[3e2t]] – TPH 1 catalytic domain + Trp + Fe – chicken
**[[3e2t]] – TPH 1 catalytic domain + Trp + Fe – chicken
Line 51: Line 56:
**[[1phh]] – PfPHBH + FAD + DHB – ''Pseudomonas fluorescens''<br />
**[[1phh]] – PfPHBH + FAD + DHB – ''Pseudomonas fluorescens''<br />
-
**[[1dob]], [[1doc]], [[1pxa]], [[1pxb]], [[1pxc]] – PaPHBH + FAD + PHB – ''Pseudomonas aeruginosa''<br />
 
**[[2phh]] – PfPHBH + adenosine diphosphoribose + PHB <br />
**[[2phh]] – PfPHBH + adenosine diphosphoribose + PHB <br />
**[[1pbb]] – PfPHBH + FAD + 2,4-DHB <br />
**[[1pbb]] – PfPHBH + FAD + 2,4-DHB <br />
Line 61: Line 65:
**[[1cj2]], [[1cj3]], [[1cj4]] – PfPHBH (mutant) + FAD derivative + PHB <br />
**[[1cj2]], [[1cj3]], [[1cj4]] – PfPHBH (mutant) + FAD derivative + PHB <br />
**[[1dob]], [[1doc]], [[1pxa]], [[1pxb]], [[1pxc]] – PaPHBH + FAD + PHB – ''Pseudomonas aeruginosa''<br />
**[[1dob]], [[1doc]], [[1pxa]], [[1pxb]], [[1pxc]] – PaPHBH + FAD + PHB – ''Pseudomonas aeruginosa''<br />
-
**[[1dod]], [[1doe]], [[1iuv]], [[1iuw]], [[1iux]] – PaPHBH + FAD + DHB derivative <br />
+
**[[1dod]], [[1doe]], [[1iuv]], [[1iuw]], [[1iux]] – PaPHBH + FAD + DHB derivative<br />
**[[1ius]], [[1iut]], [[1iuu]] – PaPHBH + FAD + 4-aminobenzoate <br />
**[[1ius]], [[1iut]], [[1iuu]] – PaPHBH + FAD + 4-aminobenzoate <br />
**[[6ju1]] – PaPHBH (mutant) + FAD + DHB derivative <br />
**[[6ju1]] – PaPHBH (mutant) + FAD + DHB derivative <br />
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**[[1k0j]] – PaPHBH (mutant) + FAD + NADPH <br />
**[[1k0j]] – PaPHBH (mutant) + FAD + NADPH <br />
**[[1k0l]] – PaPHBH (mutant) + FAD <br />
**[[1k0l]] – PaPHBH (mutant) + FAD <br />
-
**[[6dll]] – PfPHBH + FAD – ''Pseudomonas putida''<br />
+
**[[5tti]], [[6dll]] – PfPHBH + FAD – ''Pseudomonas putida''<br />
-
**[[2dki]] – CtPHBH + FAD – ''Comamonas testosteroni''<br />
+
**[[2dki]] – CtPHBH + FAD – Comamonas testosteroni<br />
**[[2dkh]] – CtPHBH + FAD + hydroxy-benzoate <br />
**[[2dkh]] – CtPHBH + FAD + hydroxy-benzoate <br />
-
*Apartyl/asparaginyl β-hydroxylase; Domain – oxygenase and TPR 301-758
+
*Apartyl/asparaginyl b-hydroxylase; Domain – oxygenase and TPR 301-758
**[[6qa5]] – hAAH oxygenase and TPR domain<br />
**[[6qa5]] – hAAH oxygenase and TPR domain<br />
Line 80: Line 84:
**[[6yyu]], [[6yyv]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn <br />
**[[6yyu]], [[6yyv]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn <br />
**[[6yyw]], [[6yyx]], [[6yyy]], [[6z6q]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn + coagulation factor X peptide<br />
**[[6yyw]], [[6yyx]], [[6yyy]], [[6z6q]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn + coagulation factor X peptide<br />
-
**[[5jz8]], [[5jzu]], [[6rk9]], [[5jqy]], [[6rk9]], [[6z6r]] – hAAH oxygenase and TPR domain + oxalyl derivative + Mn + coagulation factor X peptide<br />
+
**[[5jz8]], [[5jzu]], [[5jzz]], [[5jqy]], [[6rk9]], [[6z6r]] – hAAH oxygenase and TPR domain + oxalyl derivative + Mn + coagulation factor X peptide<br />
**[[7e6j]] – hAAH oxygenase and TPR domain (mutant) + coagulation factor X peptide<br />
**[[7e6j]] – hAAH oxygenase and TPR domain (mutant) + coagulation factor X peptide<br />
**[[6q9f]], [[6q9i]] – hAAH oxygenase and TPR domain (mutant) + oxalylglycine + Mn + coagulation factor X peptide<br />
**[[6q9f]], [[6q9i]] – hAAH oxygenase and TPR domain (mutant) + oxalylglycine + Mn + coagulation factor X peptide<br />
Line 87: Line 91:
*Alpha-ketoglutarate-dependent L-arginine hydroxylase
*Alpha-ketoglutarate-dependent L-arginine hydroxylase
-
**[[6dax]], [[6alm]], [[6aln]], [[6mp8]] – SvAAH + arginine + oxoglutarate + Fe – ''Streptomyces vinaceus''<br />
+
**[[6dax]], [[6alm]], [[6aln]], [[6mp8]] – SvAAH + arginine + oxoglutarate + Fe – Streptomyces vinaceus<br />
**[[6daz]], [[6alo]], [[6alp]], [[6alq]], [[6y12]] – SvAAH + arginine + succinate + Fe <br />
**[[6daz]], [[6alo]], [[6alp]], [[6alq]], [[6y12]] – SvAAH + arginine + succinate + Fe <br />
**[[6y0n]] – SvAAH + arginine + AKG + Fe <br />
**[[6y0n]] – SvAAH + arginine + AKG + Fe <br />
Line 95: Line 99:
*PLP-dependent L-arginine hydroxylase
*PLP-dependent L-arginine hydroxylase
-
**[[6c9b]] – SwAAH + PLP – ''Streptomyces wadayamensis''<br />
+
**[[6c9b]] – SwAAH + PLP – Streptomyces wadayamensis<br />
**[[5dj1]] – SwAAH + PLP + Mg<br />
**[[5dj1]] – SwAAH + PLP + Mg<br />
**[[5dj3]] – SwAAH + PLP-arginine + Mg<br />
**[[5dj3]] – SwAAH + PLP-arginine + Mg<br />
Line 103: Line 107:
*Leucine hydroxylase
*Leucine hydroxylase
-
**[[5nch]] – StAAH – ''Streptomyces'' <br />
+
**[[5nch]] – StAAH – Streptomyces <br />
**[[5nci]] – StAAH + leucine derivative + oxoglutarate + Co <br />
**[[5nci]] – StAAH + leucine derivative + oxoglutarate + Co <br />
**[[5ncj]] – StAAH + leucine derivative + succinate + Mn <br />
**[[5ncj]] – StAAH + leucine derivative + succinate + Mn <br />
Line 109: Line 113:
*L-arginine b-hydroxylase or non-heme iron oxygenase
*L-arginine b-hydroxylase or non-heme iron oxygenase
-
**[[4m23]] – SlORFP – ''Streptomyces lavendulae''<br />
+
**[[4m23]] – SlORFP – Streptomyces lavendulae<br />
**[[4m2i]] – SlORFP + Fe <br />
**[[4m2i]] – SlORFP + Fe <br />
**[[4m25]] – SlORFP + Fe + ketoglutarate <br />
**[[4m25]] – SlORFP + Fe + ketoglutarate <br />
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**[[4m2f]] – SlORFP + Fe + canavanine<br />
**[[4m2f]] – SlORFP + Fe + canavanine<br />
**[[4m2g]], [[4m26]] – SlORFP + Fe + succinate + Arg derivative<br />
**[[4m2g]], [[4m26]] – SlORFP + Fe + succinate + Arg derivative<br />
-
**[[2wbo]] – SvVIOC + Fe + Arg – ''Streptomyces vinaceus''<br />
+
**[[2wbo]] – SvVIOC + Fe + Arg – Streptomyces vinaceus<br />
**[[2wbq]] – SvVIOC + Arg derivative<br />
**[[2wbq]] – SvVIOC + Arg derivative<br />
**[[2wbp]] – SvVIOC + Fe + succinate + Arg derivative<br />
**[[2wbp]] – SvVIOC + Fe + succinate + Arg derivative<br />
-
**[[6daw]] – NAPI + Fe + Arg – ''Streptomyces lusitanus''<br />
+
**[[6daw]] – NAPI + Fe + Arg – Streptomyces lusitanus<br />
-
*Prolyl 4-hydroxylase
+
*Prolyl 4-hydroxylase
**[[4bt8]], [[2yq8]] - hPH a1 subunit collagen-binding domain<br />
**[[4bt8]], [[2yq8]] - hPH a1 subunit collagen-binding domain<br />
**[[1tjc]] - hPH a1 subunit collagen-binding domain (mutant)<br />
**[[1tjc]] - hPH a1 subunit collagen-binding domain (mutant)<br />
-
**[[4btb]], [[4bta]], [[4bt9]] - hPH a1 subunit + peptide<br />
+
**[[2v5f]], [[4btb]], [[4bta]], [[4bt9]] - hPH a1 subunit + peptide<br />
**[[6evl]] - hPH a2 subunit <br />
**[[6evl]] - hPH a2 subunit <br />
**[[6evm]], [[6evn]], [[6evo]], [[6evp]] - hPH a2 subunit + peptide<br />
**[[6evm]], [[6evn]], [[6evo]], [[6evp]] - hPH a2 subunit + peptide<br />
-
**[[5hv0]] - PH + Cd – ''Bacillus anthracis'' <br />
+
**[[3itq]], [[5hv0]] - BaPH – Bacillus anthracis <br />
 +
**[[5hv4]] - BaPH + ketoglutarate<br />
**[[5c5u]] - PcvPH + Mn – Paramecium chlorella virus <br />
**[[5c5u]] - PcvPH + Mn – Paramecium chlorella virus <br />
**[[5c5t]] - PcvPH + Mn + Zn <br />
**[[5c5t]] - PcvPH + Mn + Zn <br />
-
**[[4p7x]] - RlPH + Co + pipecolic acid – ''Rhizobium loti'' <br />
+
**[[4p7x]] - RlPH + Co + pipecolic acid – Rhizobium loti <br />
**[[4p7w]] - RlPH + Co + proline<br />
**[[4p7w]] - RlPH + Co + proline<br />
-
**[[6iuq]] - PH + Fe – ''Phytophthora capsici''<br />
+
**[[6iuq]] - PH + Fe – Phytophthora capsici<br />
-
**[[2v4a]], [[2jij]] - CrPH – ''Chlamydomonas reinhardtii'' <br />
+
**[[2v4a]], [[2jij]] - CrPH – Chlamydomonas reinhardtii <br />
**[[2jig]] - CrPH + Zn + pyridine derivative<br />
**[[2jig]] - CrPH + Zn + pyridine derivative<br />
 +
**[[3gze]] - CrPH + Zn + peptide<br />
-
*HIF prolyl hydroxylase or egl nine homolog See [[Prolyl hydroxylase domain]]
+
*HIF prolyl hydroxylase or egl nine homolog
-
*Lysine 4-hydroxylase
+
See [[Prolyl hydroxylase domain]]
-
**[[6f9p]] – FlL4H + Fe – ''Flavobacterium'' <br />
+
*Lysine 4-hydroxylase
 +
 
 +
**[[6f9p]] – FlL4H + Fe – Flavobacterium <br />
**[[6exf]] – FlL4H + Fe + lysine <br />
**[[6exf]] – FlL4H + Fe + lysine <br />
**[[6euo]] – FlL4H + Fe + succinate derivative<br />
**[[6euo]] – FlL4H + Fe + succinate derivative<br />
Line 147: Line 155:
**[[6exh]] – FlL4H + Fe + lysine + succinate<br />
**[[6exh]] – FlL4H + Fe + lysine + succinate<br />
-
*Lysine 3-hydroxylase
+
*Lysine 3-hydroxylase
-
**[[6f2e]] – CaL3H – ''Catenulispora acidiphila'' <br />
+
**[[6f2e]] – CaL3H – Catenulispora acidiphila <br />
**[[6f2b]] – CaL3H + Fe + oxoglutarate <br />
**[[6f2b]] – CaL3H + Fe + oxoglutarate <br />
**[[6f2a]] – CaL3H + Fe + lysine <br />
**[[6f2a]] – CaL3H + Fe + lysine <br />
Line 156: Line 164:
*Salicylate hydroxylase
*Salicylate hydroxylase
 +
**[[6bz5]] - PpSH <br />
**[[5evy]] - PpSH + FAD + salicilate <br />
**[[5evy]] - PpSH + FAD + salicilate <br />
 +
**[[7c8z]] - SH + Fe2S2 + Fe - Ralstonia <br />
-
*Dopamine β-hydroxylase
+
*Dopamine b-hydroxylase (cofactor ascorbic acid)
**[[4zel]] - hDH + Cu <br />
**[[4zel]] - hDH + Cu <br />
Line 164: Line 174:
*Ectoine hydroxylase
*Ectoine hydroxylase
-
**[[4mhr]] - SaEH – ''Sphingopyxis alaskensis'' <br />
+
**[[4mhr]] - SaEH – Sphingopyxis alaskensis <br />
**[[4mhu]] - SaEH + Fe <br />
**[[4mhu]] - SaEH + Fe <br />
-
**[[4q5o]] - SaEH + Fe + 5-hydroxyectoine<br />
+
**[[4q5o]] - SaEH + Fe + 5-hydroxyectoine <br />
-
**[[4nmi]] - VsEH – ''Virgibacillus salexigens''<br />
+
**[[4nmi]] - VsEH – Virgibacillus salexigens<br />
**[[3emr]] - VsEH + Fe <br />
**[[3emr]] - VsEH + Fe <br />
Line 175: Line 185:
**[[6tto]] - dHH + Ni + oxoglutaratee <br />
**[[6tto]] - dHH + Ni + oxoglutaratee <br />
-
*Cytochrome P450 hydroxylase See [[Cytochrome P450 hydroxylase]]
+
*Cytochrome P450 hydroxylase
 +
 
 +
See [[Cytochrome P450 hydroxylase]]
 +
 
 +
*Toluene/o-xylene monooxygenase hydroxylase
 +
 
 +
See [[Monooxygenase]]
 +
 
 +
*Ornithine hydroxylase
 +
 
 +
See [[Monooxygenase]]
 +
 
 +
*Methane monooxygenase hydroxylase
 +
 
 +
See [[Methane monooxygenase]]
 +
 
 +
*Kynurenine 3-hydroxylase or KMO
 +
 
 +
See [[Monooxygenase]]
 +
 
 +
*Trans-3/4-proline hydroxylase H11
 +
 
 +
See [[Dioxygenase]]
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:14, 24 May 2023

3D structures of hydroxylases

Updated on 24-May-2023

See Prolyl hydroxylase domain

See Cytochrome P450 hydroxylase

See Monooxygenase

See Monooxygenase

See Methane monooxygenase

See Monooxygenase

See Dioxygenase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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