8j1i
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of EphA8/SASH1 Complex== | |
| - | + | <StructureSection load='8j1i' size='340' side='right'caption='[[8j1i]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8j1i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J1I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j1i OCA], [https://pdbe.org/8j1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j1i RCSB], [https://www.ebi.ac.uk/pdbsum/8j1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j1i ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EPHA8_MOUSE EPHA8_MOUSE] Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.<ref>PMID:10498895</ref> <ref>PMID:11416136</ref> <ref>PMID:12681484</ref> <ref>PMID:15782114</ref> <ref>PMID:17875921</ref> <ref>PMID:9214628</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Ding Y]] | ||
| + | [[Category: Li J]] | ||
| + | [[Category: Liu W]] | ||
Revision as of 09:37, 1 March 2024
Crystal Structure of EphA8/SASH1 Complex
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Categories: Large Structures | Mus musculus | Ding Y | Li J | Liu W
