8oio

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Current revision (05:48, 3 April 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8oio is ON HOLD until Paper Publication
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==Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide==
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<StructureSection load='8oio' size='340' side='right'caption='[[8oio]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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Authors: Dalietou, E.V., Chen, Z., Ramdass, A.E., Manning, C., Richardson, W., Aitmakhanova, K., Platt, M., Pike, A., Fedorov, O., Brennan, P., Bullock, A.N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8oio]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OIO FirstGlance]. <br>
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Description: Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.954&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Manning, C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oio OCA], [https://pdbe.org/8oio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oio RCSB], [https://www.ebi.ac.uk/pdbsum/8oio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oio ProSAT]</span></td></tr>
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[[Category: Pike, A]]
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</table>
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[[Category: Aitmakhanova, K]]
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== Function ==
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[[Category: Dalietou, E.V]]
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[https://www.uniprot.org/uniprot/KLH12_HUMAN KLH12_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export (PubMed:27716508). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (PubMed:16547521). The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins (PubMed:18303015, PubMed:20100572, PubMed:27716508).<ref>PMID:16547521</ref> <ref>PMID:18303015</ref> <ref>PMID:20100572</ref> <ref>PMID:22358839</ref> <ref>PMID:27565346</ref> <ref>PMID:27716508</ref>
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[[Category: Fedorov, O]]
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== References ==
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[[Category: Chen, Z]]
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<references/>
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[[Category: Richardson, W]]
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__TOC__
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[[Category: Ramdass, A.E]]
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</StructureSection>
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[[Category: Brennan, P]]
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[[Category: Homo sapiens]]
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[[Category: Platt, M]]
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[[Category: Large Structures]]
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[[Category: Bullock, A.N]]
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[[Category: Aitmakhanova K]]
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[[Category: Brennan P]]
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[[Category: Bullock AN]]
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[[Category: Chen Z]]
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[[Category: Dalietou EV]]
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[[Category: Fedorov O]]
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[[Category: Manning C]]
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[[Category: Pike A]]
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[[Category: Platt M]]
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[[Category: Ramdass AE]]
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[[Category: Richardson W]]

Current revision

Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide

PDB ID 8oio

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