8oq7

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'''Unreleased structure'''
 
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The entry 8oq7 is ON HOLD until Paper Publication
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==CryoEM structure of human rho1 GABAA receptor in complex with inhibitor TPMPA==
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<StructureSection load='8oq7' size='340' side='right'caption='[[8oq7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8oq7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OQ7 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=VZA:methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic+acid'>VZA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oq7 OCA], [https://pdbe.org/8oq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oq7 RCSB], [https://www.ebi.ac.uk/pdbsum/8oq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oq7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GBRR1_HUMAN GBRR1_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen F]]
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[[Category: Erik L]]
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[[Category: John C]]
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[[Category: Rebecca JH]]
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[[Category: Victor T]]

Revision as of 09:15, 30 August 2023

CryoEM structure of human rho1 GABAA receptor in complex with inhibitor TPMPA

PDB ID 8oq7

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