Insulin 3D Structures

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

(Updated on 22-September-2025)

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Insulin_3D_Structures"

Category: Topic Page

@@ Line 4: / Line 4: @@
 * Insulin
-**[[5bts]], [[4ak0]], [[2lgb]], [[1guj]], [[2c8r]], [[2c8q]], [[3i40]], [[3i3z]], [[5en9]], [[3zi3]], [[6s34]], [[6h3m]], [[6o17]], [[6s34]], [[7ac4]], [[7jp3]], [[7qgf]], [[7s4y]], [[7z5l]], [[7z5q]], [[8gsg]] - hIns A chain + B chain – human<br />
+**[[1guj]], [[2c8q]], [[2c8r]], [[2lgb]], [[3i3z]], [[3i40]], [[3zi3]], [[4ak0]], [[5bts]], [[5en9]], [[6h3m]], [[6o17]], [[6s34]], [[7ac4]], [[7jp3]], [[7nhu]], [[7qgf]], [[7s4y]], [[7z5l]], [[7z5q]], [[8gsg]], [[8z4b]], [[9m50]], [[9m51]] - hIns A chain + B chain – human<br />
 **[[6jr3]] - hIns A chain + B chain – Cryo EM<br />
-**[[3e7y]], [[3e7z]], [[2qiu]], [[1os3]], [[1os4]], [[1mso]], [[1g7a]], [[1g7b]], [[1trz]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]] [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4p65]], [[2vjz]], [[2vk0]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[5ems]], [[5e7w]], [[5co9]], [[5co6]], [[5co2]], [[6gv0]], [[6zi8]] - hIns A chain + B chain + Zn<br />
+**[[1g7a]], [[1g7b]], [[1mso]], [[1os3]], [[1os4]], [[1trz]], [[2qiu]], [[2vjz]], [[2vk0]], [[3e7y]], [[3e7z]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]] [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4p65]], [[5co2]], [[5co6]], [[5co9]], [[5ems]], [[5e7w]], [[6gv0]], [[6zi8]], [[8hgz]], [[9lvc]], [[9lvd]], [[9lve]], [[9m4x]], [[9m4y]], [[9m4z]] - hIns A chain + B chain + Zn<br />
 **[[1fu2]], [[1fub]] - hIns A chain + B chain + Zn – powder diffraction<br />
-**[[5t7r]] - hIns A chain (mutant) + B chain<br />
+**[[5t7r]], [[8rrp]] - hIns A chain (mutant) + B chain<br />
-**[[1b9e]], [[3u4n]], [[4iuz]], [[4une]], [[4ung]], [[4unh]], [[5ena]], [[2ws4]], [[7nhu]] - hIns A chain + B chain (mutant)<br />
+**[[1b9e]], [[2ws4]], [[3u4n]], [[4iuz]], [[4une]], [[4ung]], [[4unh]], [[5ena]], [[7nhu]], [[8hsf]], [[8hsk]]  - hIns A chain + B chain (mutant)<br />
-**[[3bxq]], [[1qj0]], [[6tyh]] – hIns A chain + B chain (mutant) + Zn<br />
+**[[1qj0]], [[3bxq]], [[6tyh]] – hIns A chain + B chain (mutant) + Zn
-**[[3ir0]], [[3inc]], [[3ilg]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]], [[4rxw]], [[4fka]], [[6p4z]] - hIns A chain + B chain + non-Zn metal ion<br />
+**[[2r34]], [[2r35]], [[2r36]], [[3exx]], [[3ilg]], [[3inc]], [[3ir0]], [[3tt8]], [[4fka]], [[4rxw]], [[6p4z]] - hIns A chain + B chain + non-Zn metal ion<br />
-**[[1jca]], [[1j73]], [[4efx]], - hIns A chain (mutant) + B chain + Zn<br />
+**[[1j73]], [[1jca]], [[4efx]], - hIns A chain (mutant) + B chain + Zn<br />
-**[[5mwq]], [[5azz]], [[6s4i]], [[6s4j]], [[6vet]] - hIns A chain (mutant) + B chain (mutant)<br />
+**[[5azz]], [[5mwq]], [[6s4i]], [[6s4j]], [[6vet]] - hIns A chain (mutant) + B chain (mutant)<br />
 **[[6p4z]] - hIns A chain + B chain + Co + Gd<br />
-**[[2g4m]], [[9ins]], [[3t2a]], [[4a7e]], [[5lis]], [[5fb6]], [[5d5e]], [[5d54]], [[5d53]], [[5d52]] - pIns A chain + B chain – pig<br />
+**[[2g4m]], [[3t2a]], [[4a7e]], [[5d52]], [[5d53]], [[5d54]], [[5d5e]], [[5fb6]], [[5lis]], [[9ins]] - pIns A chain + B chain – pig<br />
 **[[1iza]] - pIns A chain + B chain (mutant)<br />
-**[[1zni]], [[4ins]], [[3ins]], [[3rto]], [[3fhp]] - pIns A chain + B chain + Zn<br />
+**[[1zni]], [[3fhp]], [[3ins]], [[3rto]], [[4ins]] - pIns A chain + B chain + Zn<br />
 **[[1izb]] - pIns A chain + B chain (mutant) + Zn<br />
-**[[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron<br />
+**[[2efa]], [[2zpp]] - pIns A chain + B chain – Neutron<br />
 **[[1m5a]] - pIns A chain + B chain + Co<br />
 **[[6ins]] – pIns single chain<br />
-**[[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[2bn1]], [[2bn3]], [[6or0]], [[6qq7]], [[6qqg]], [[6qrh]], [[6qrk]] - bIns A chain + B chain – bovine<br />
+**[[1aph]], [[1bph]], [[1cph]], [[1dph]], [[2bn1]], [[2bn3]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[6or0]], [[6qq7]], [[6qqg]], [[6qrh]], [[6qrk]] - bIns A chain + B chain – bovine<br />
-**[[2zp6]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[2a3g]], - bIns A chain + B chain + Zn <br />
+**[[2a3g]], [[2zp6]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]] - bIns A chain + B chain + Zn <br />
 **[[6zhb]] - bIns A chain + B chain + Zn – electron diffraction<br />
 **[[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain + non-Zn metal ion<br />
@@ Line 30: / Line 30: @@
 *Insulin structures using NMR
-**[[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1xgl]], [[2mvc]], [[2kxk]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[2hiu]], [[2jv1]], [[6x4x]] - hIns A chain + B chain – NMR<br />
+**[[1sf1]], [[1xgl]], [[2aiy]], [[2hiu]], [[2jv1]], [[2kxk]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[2mvc]], [[3aiy]], [[4aiy]], [[5aiy]], [[6x4x]] - hIns A chain + B chain – NMR<br />
 **[[1ai0]], [[1aiy]] - hIns A chain + B chain + Zn – NMR<br />
 **[[1t1k]], [[1t1p]], [[1t1q]], [[2mpg]], [[2mpi]], [[2l1z]], [[5mhd]] - hIns A chain (mutant) + B chain – NMR<br />
-**[[2jmn]], [[2h67]], [[2hho]], [[1jco]], [[1a7f]], [[2mvd]], [[2kjj]], [[2k91]], [[2rn5]], [[1hiq]], [[1hit]]  - hIns A chain + B chain (mutant) – NMR<br />
+**[[1a7f]], [[1jco]], [[1hiq]], [[1hit]], [[2h67]], [[2hho]], [[2jmn]], [[2kjj]], [[2k91]], [[2mvd]], [[2rn5]] - hIns A chain + B chain (mutant) – NMR<br />
-**[[2jum]], [[2juv]], [[1k3m]], [[1vkt]], [[1hui]], [[1mhi]], [[1mhj]], [[1hls]], [[1lkq]], [[2m1d]] - hIns A chain (mutant) + B chain (mutant) – NMR<br />
+**[[1hls]], [[1hui]], [[1k3m]], [[1lkq]], [[1mhi]], [[1mhj]], [[1vkt]], [[2jum]], [[2juv]], [[2m1d]] - hIns A chain (mutant) + B chain (mutant) – NMR<br />
 **[[2kqq]], [[2l1y]] - hIns A chain (mutant) + B chain + Ala – NMR<br />
 **[[2kjr]] - hIns A chain + B chain (mutant) + Ala – NMR<br />
@@ Line 45: / Line 45: @@
 **[[2lwz]], [[5wbt]] – hIns single chain - NMR<br />
 **[[2jzq]] – hIns single chain (mutant) - NMR<br />
+**[[8rvt]] - hIns A chain 25-53 + hInsLis B chain 90-110 - NMR<br />
 **[[1ho0]] - bIns B chain (mutant) – NMR<br />
 **[[5miz]], [[6kh8]], [[6kh9]], [[6kha]] - bIns A chain + B chain – NMR<br />
@@ Line 50: / Line 51: @@
 *Insulin complexes
-**[[4xc4]] - hIns A chain + B chain + sulfatide + Zn<br />
+**[[3brr]] - hIns A chain + B chain + sulfatide + Zn<br />
 **[[1ben]] - hIns A chain + B chain + hydroxybenzamide + Zn<br />
 **[[1tyl]], [[1tym]] - hIns A chain + B chain + hydroxyacetanilide + Zn<br />
+**[[8onp]], [[8onr]] - hIns A chain + B chain + hydroxyproline + Zn<br />
 **[[5boq]] - hIns A chain + B chain + norleucine<br />
 **[[5bpo]] - hIns A chain + B chain + norvaline<br />
@@ Line 58: / Line 60: @@
 **[[2mli]] - hIns A chain + B chain + Phe derivative<br />
 **[[2ws1]] - hIns A chain + B chain + Tyr derivative<br />
-**[[5hqi]], [[5hpr]], [[4cxl]], [[2wrw]] - hIns A chain + B chain (mutant) + Pro derivative<br />
+**[[2wrw]], [[4cxl]], [[5hpr]], [[5hqi]] - hIns A chain + B chain (mutant) + Pro derivative<br />
 **[[4nib]] - hIns A chain (mutant) + B chain + Ala <br />
 **[[3fq9]] - hIns A chain (mutant) + B chain + Ala + Zn<br />
-**[[4cxn]], [[4cy7]], [[2wru]], [[2wrx]], [[2ws0]] - hIns A chain + B chain (mutant) + Ala derivative<br />
+**[[2wru]], [[2wrx]], [[2ws0]], [[4cxn]], [[4cy7]] - hIns A chain + B chain (mutant) + Ala derivative<br />
 **[[2wrv]] - hIns A chain + B chain (mutant) + His derivative<br />
 **[[2oly]], [[2om0]], [[2omh]], [[2omi]] - hIns A chain + B chain + urea + resorcinol + Zn<br />
 **[[2omg]] - hIns A chain + B chain + urea + cresol + Zn<br />
 **[[2olz]], [[2om1]] - hIns A chain + B chain + thiocyanate + resorcinol + Zn<br />
-**[[4akj]], [[4ajz]], [[3v19]], [[1znj]] - hIns A chain + B chain + phenol + Zn<br />
+**[[1znj]], [[3v19]], [[4ajz]], [[4akj]] - hIns A chain + B chain + phenol + Zn<br />
-**[[3kq6]], [[1xw7]], [[1rwe]] - hIns A chain (mutant) + B chain + phenol + Zn<br />
+**[[1rwe]], [[1xw7]], [[3kq6]] - hIns A chain (mutant) + B chain + phenol + Zn<br />
-**[[1w8p]], [[2ws7]], [[1qiy]] - hIns A chain + B chain (mutant) + phenol + Zn<br />
+**[[1qiy]], [[1w8p]], [[2ws7]] - hIns A chain + B chain (mutant) + phenol + Zn<br />
-**[[1zeg]], [[1lph]] - hIns A chain (mutant) + B chain (mutant) + phenol + Zn<br />
+**[[1lph]], [[1zeg]] - hIns A chain (mutant) + B chain (mutant) + phenol + Zn<br />
 **[[3v1g]] - hIns A chain + B chain + phenol + Glu + Zn<br />
 **[[1q4v]] - hIns A chain + B chain + phenol + Ile + Zn<br />
-**[[3rov]], [[3p2x]] - hIns A chain + B chain (mutant) + phenol + Ala + Zn<br />
+**[[3p2x]], [[3rov]] - hIns A chain + B chain (mutant) + phenol + Ala + Zn<br />
-**[[5hpu]], [[5uu4]], [[5uu3]], [[5uu2]], [[5usv]], [[5uss]], [[5usp]], [[5uru]], [[5urt]], [[5uqa]], [[5uoz]] - hIns A chain + B chain + phenol + Pro derivative + Zn<br />
+**[[5hpu]], [[5uoz]], [[5uqa]], [[5urt]], [[5uru]], [[5usp]], [[5uss]], [[5usv]], [[5uu2]], [[5uu3]], [[5uu4]]  - hIns A chain + B chain + phenol + Pro derivative + Zn<br />
 **[[5hrq]] - hIns A chain + B chain (mutant) + phenol + Pro derivative + Zn<br />
-**[[3zs2]], [[3zqr]] - hIns A chain + B chain + phenol + Phe derivative + Zn<br />
+**[[3zqr]], [[3zs2]] - hIns A chain + B chain + phenol + Phe derivative + Zn<br />
 **[[2ws6]] - hIns A chain + B chain + phenol + Tyr derivative + Zn<br />
 **[[1xda]] - hIns A chain + B chain + phenol + myristic acid + Zn<br />
 **[[6ck2]] - hIns A chain + B chain (mutant) + phenol + ornithine + Zn<br />
 **[[1qiz]] - hIns A chain (mutant) + B chain (mutant) + resorcinol + Zn<br />
-**[[1ev3]], [[1ev6]], [[1uz9]], [[4gbn]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[6gnq]] - hIns A chain + B chain + cresol + Zn<br />
+**[[1ev3]], [[1ev6]], [[1uz9]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[6gnq]] - hIns A chain + B chain + cresol + Zn<br />
 **[[1zeh]] - hIns A chain (mutant) + B chain (mutant) + cresol + Zn<br />
-**[[1evr]], [[4ajx]], [[3zu1]] - hIns A chain + B chain + resorcinol + Zn<br />
+**[[1evr]], [[3zu1]], [[4ajx]] - hIns A chain + B chain + resorcinol + Zn<br />
 **[[5mam]] - hIns A chain + B chain + serotonin + Zn<br />
-**[[5mt9]], [[5mt3]] - hIns A chain + B chain + serotonin + arginine + Zn<br />
+**[[5mt3]], [[5mt9]] - hIns A chain + B chain + serotonin + arginine + Zn<br />
 **[[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate<br />
-**[[1mpj]], [[3gky]], [[1wav]] - pIns A chain + B chain + phenol + Zn<br />
+**[[1mpj]], [[1wav]], [[3gky]] - pIns A chain + B chain + phenol + Zn<br />
 **[[2tci]] - pIns A chain + B chain + thiocyanate + Zn<br />
 **[[3mth]] - pIns A chain + B chain + methylparaben + Zn<br />
 **[[7ins]] - pIns A chain + B chain + clupeine + cresol + Zn<br />
-**[[5jyq]] - CgIns A chain + B chain + Pro derivative – ''Conus geographus''<br />
+**[[5jyq]] - CgIns A chain + B chain + Pro derivative – Conus geographus<br />
 *Insulin complexes with protein
 **[[3q6e]] - hIns A chain + B chain + synthetic receptor<br />
-**[[7bw7]], [[7bw8]], [[7bwa]], [[7pg0]], [[7pg2]], [[7pg3]], [[7pg4]], [[7qid]], [[7sth]], [[7sti]], [[7stj]], [[7stk, [[8guy]] - hIns A chain + B chain + insulin receptor – Cryo EM<br />
+**[[7bw7]], [[7bw8]], [[7bwa]], [[7pg0]], [[7pg2]], [[7pg3]], [[7pg4]], [[7qid]], [[7sth]], [[7sti]], [[7stj]], [[7stk]], [[8guy]] - hIns A chain + B chain + insulin receptor – Cryo EM<br />
 **[[7l7j]], [[7sl1]], [[7sl2]], [[7sl3]] - hIns A chain (mutant) + B chain + insulin receptor – Cryo EM<br />
 **[[7sl4]], [[7sl6]] - hIns A chain + B chain (mutant) + insulin receptor – Cryo EM<br />
@@ Line 101: / Line 103: @@
 **[[7yq3]], [[7yq4]], [[7yq5]], [[7yq6]] - hIns A chain + B chain + insulin receptor + DNA – Cryo EM<br />
 **[[2g54]], [[2g56]] - hIns B chain + insulin-degrading enzyme + Zn<br />
-**[[6b3q]] - hIns A chain + B chain + insulin-degrading enzyme<br />
+**[[6b3q]] - hIns A chain + B chain + insulin-degrading enzyme <br />
 **[[6b3q]], [[6bfc]] - hIns A chain + B chain + insulin-degrading enzyme – Cryo EM<br />
 **[[2wby]], [[2wc0]] - hIns A chain + B chain + insulin-degrading enzyme (mutant) + Zn<br />
-**[[3w11]], [[5kqv]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
+**[[8oni]], [[8onk]] - hIns A chain + B chain enzyme + antibody<br />
+**[[3w11]], [[3w14]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
 **[[6b70]] - hIns A chain + B chain + insulin-degrading enzyme + antibody – Cryo EM<br />
 **[[6jk8]], [[7v3p]] - hIns A chain + B chain + IGF-1R – Cryo EM<br />
+**[[8vjb]] - hIns A chain + B chain + IGF-2 – Cryo EM<br />
 **[[5wob]] - hIns A chain + B chain + insulin-degrading enzyme + antibody + Zn<br />
 **[[4oga]], [[6vep]] - hIns A chain + B chain + insulin receptor + antibody<br />
-**[[6ce7]], [[6ce9]], [[6ceb]], [[6hn5]] - hIns A chain + B chain + insulin receptor – Cryo EM<br />
+**[[6ce7]], [[6ce9]], [[6ceb]], [[6hn5]], [[6pxv]], [[6pxw]], [[6sof]] - hIns A chain + B chain + insulin receptor – Cryo EM<br />
 **[[6z7w]], [[6z7y]], [[6z7z]] - pIns A chain + B chain + antibody<br />
 **[[6z7z]] - pIns A chain + B chain + antibody<br />
@@ Line 146: / Line 150: @@
 **[[4iyd]], [[4iyf]], [[5viz]] – hIns – synthetic<br />
+**[[8wu0]] - hIns A chain + hInsLis B chain + Zn<br />
+*Insulin detemir
+**[[8ipz]], [[9lvx]], [[9lvy]] - hIns A chain + hInsLis B chain + Zn<br />
+*Insulin desB30 precursor
+**[[8pi4]], [[8pi5]], [[8pjc]], [[8pjh]] - hIns A chain 25-53 + hInsLis B chain 90-110 <br />
 }}
 [[Category:Topic Page]]

Insulin 3D Structures

From Proteopedia

Current revision

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox