8jeo
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of TIGIT in complexed with Tiragolumab== | |
| - | + | <StructureSection load='8jeo' size='340' side='right'caption='[[8jeo]], [[Resolution|resolution]] 2.06Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8jeo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JEO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jeo OCA], [https://pdbe.org/8jeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jeo RCSB], [https://www.ebi.ac.uk/pdbsum/8jeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jeo ProSAT]</span></td></tr> |
| - | [[Category: Song | + | </table> |
| - | [[Category: Sun | + | == Function == |
| - | [[Category: Zhang | + | [https://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Song J]] | ||
| + | [[Category: Sun J]] | ||
| + | [[Category: Zhang XX]] | ||
Revision as of 09:38, 1 March 2024
Crystal structure of TIGIT in complexed with Tiragolumab
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