8slo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8slo is ON HOLD until Paper Publication
+
==Plasmodium falciparum M1 aminopeptidase bound to selective inhibitor MIPS2673==
-
 
+
<StructureSection load='8slo' size='340' side='right'caption='[[8slo]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8slo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SLO FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BYW:2-hydroxy-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3,4,5-trifluoro[1,1-biphenyl]-4-yl)ethyl]-2-methylpropanamide'>BYW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8slo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8slo OCA], [https://pdbe.org/8slo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8slo RCSB], [https://www.ebi.ac.uk/pdbsum/8slo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8slo ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AMPN_PLAF7 AMPN_PLAF7] Displays aminopeptidase activity with a broad substrate specificity (PubMed:9879894, PubMed:12166515, PubMed:21659511, PubMed:22359643, PubMed:34133730, PubMed:33536500, PubMed:19196988, PubMed:21844374, PubMed:23897806). Preferentially, cleaves after Leu and Met, but cleaves also after Ala and Arg (PubMed:12166515, PubMed:22359643, PubMed:33536500, PubMed:21844374). Low activity towards Lys, Phe, Tyr, Trp, Gln, Ser and Gly and negligible activity towards Glu, Asp, Pro, Ile, Thr, Val, His and Asn (PubMed:22359643). Has dipeptidase activity (PubMed:21659511, PubMed:23897806). Plays a role in the terminal stages of host hemoglobin digestion by cleaving the N-terminal residue of small hemoglobin-derived oligopeptides (PubMed:21659511, PubMed:34133730, PubMed:21844374).<ref>PMID:12166515</ref> <ref>PMID:19196988</ref> <ref>PMID:21659511</ref> <ref>PMID:21844374</ref> <ref>PMID:22359643</ref> <ref>PMID:23897806</ref> <ref>PMID:33536500</ref> <ref>PMID:34133730</ref> <ref>PMID:9879894</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Plasmodium falciparum]]
 +
[[Category: Drinkwater N]]
 +
[[Category: McGowan SM]]

Revision as of 05:50, 3 April 2024

Plasmodium falciparum M1 aminopeptidase bound to selective inhibitor MIPS2673

PDB ID 8slo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8slo"
Personal tools