This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


8sv9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:12, 27 March 2024) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8sv9 is ON HOLD until Paper Publication
+
==Crystal structure of ULK1 kinase domain with inhibitor MR-2088==
-
 
+
<StructureSection load='8sv9' size='340' side='right'caption='[[8sv9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
Authors: Schonbrunn, E., Sun, L.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8sv9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SV9 FirstGlance]. <br>
-
Description: Crystal structure of ULK1 kinase domain with inhibitor MR-2088
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=WXH:(4P)-4-[(2P)-2-(1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(2,2,2-trifluoroethyl)thiophene-2-carboxamide'>WXH</scene></td></tr>
-
[[Category: Schonbrunn, E]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sv9 OCA], [https://pdbe.org/8sv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sv9 RCSB], [https://www.ebi.ac.uk/pdbsum/8sv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sv9 ProSAT]</span></td></tr>
-
[[Category: Sun, L]]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ULK1_HUMAN ULK1_HUMAN] Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.<ref>PMID:18936157</ref> <ref>PMID:21460634</ref> <ref>PMID:21795849</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Schonbrunn E]]
 +
[[Category: Sun L]]

Current revision

Crystal structure of ULK1 kinase domain with inhibitor MR-2088

PDB ID 8sv9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8sv9"
Personal tools