1kxu

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[[Image:1kxu.gif|left|200px]]
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{{Seed}}
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[[Image:1kxu.png|left|200px]]
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{{STRUCTURE_1kxu| PDB=1kxu | SCENE= }}
{{STRUCTURE_1kxu| PDB=1kxu | SCENE= }}
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'''CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE'''
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===CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE===
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==Overview==
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Cyclin-dependent kinases (CDKs), which play a key role in cell cycle control, are activated by the CDK activating kinase (CAK), which activates cyclin-bound CDKs by phosphorylation at a specific threonine residue. Vertebrate CAK contains two key components: a kinase subunit with homology to its substrate CDKs and a regulatory subunit with homology to cyclins. We have determined the X-ray crystal structure of the regulatory subunit of CAK, cyclin H, at 2.6 A resolution. Cyclin H contains two alpha-helical core domains with a fold similar to that of cyclin A, a regulatory subunit of CAK substrate CDK2, and of TFIIB, a transcription factor. Outside of the core domains, the N- and C-terminal regions of the three structures are completely different. The conformational differences between cyclin H and A structures may reflect functional differences between the two cyclins.
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The line below this paragraph, {{ABSTRACT_PUBMED_8836101}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8836101 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8836101}}
==About this Structure==
==About this Structure==
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[[Category: Nuclear protein]]
[[Category: Nuclear protein]]
[[Category: Regulatory protein]]
[[Category: Regulatory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:18:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:15:16 2008''

Revision as of 08:15, 2 July 2008

Image:1kxu.png

Template:STRUCTURE 1kxu

CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE

Template:ABSTRACT PUBMED 8836101

About this Structure

1KXU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase., Kim KK, Chamberlin HM, Morgan DO, Kim SH, Nat Struct Biol. 1996 Oct;3(10):849-55. PMID:8836101

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