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5b7w
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5b7w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris_str._8004 Xanthomonas campestris pv. campestris str. 8004]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B7W FirstGlance]. <br> | <table><tr><td colspan='2'>[[5b7w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris_str._8004 Xanthomonas campestris pv. campestris str. 8004]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B7W FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b7w OCA], [https://pdbe.org/5b7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b7w RCSB], [https://www.ebi.ac.uk/pdbsum/5b7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b7w ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b7w OCA], [https://pdbe.org/5b7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b7w RCSB], [https://www.ebi.ac.uk/pdbsum/5b7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b7w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/Y3703_XANC8 Y3703_XANC8] | [https://www.uniprot.org/uniprot/Y3703_XANC8 Y3703_XANC8] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | As an important bacterial second messenger, bis-(3',5')-cyclic diguanylate (cyclic di-GMP or c-di-GMP) has been implicated in numerous biological activities, including biofilm formation, motility, survival and virulence. These processes are manipulated by the binding of c-di-GMP to its receptors. XC_3703 from the plant pathogen Xanthomonas campestris pv. campestris, which belongs to the YajQ family of proteins, has recently been identified as a potential c-di-GMP receptor. XC_3703, together with XC_2801, functions as a transcription factor activating virulence-related genes, which can be reversed by the binding of c-di-GMP to XC_3703. However, the structural basis of how c-di-GMP regulates XC_3703 remains elusive. In this study, the structure of XC_3703 was determined to 2.1 A resolution using the molecular-replacement method. The structure of XC_3703 consists of two domains adopting the same topology, which is similar to that of the RNA-recognition motif (RRM). Arg65, which is conserved among the c-di-GMP-binding subfamily of the YajQ family of proteins, together with Phe80 in domain II, forms a putative c-di-GMP binding site. | ||
| - | |||
| - | Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv. campestris.,Zhao Z, Wu Z, Zhang J Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):720-5. doi:, 10.1107/S2053230X16013017. Epub 2016 Aug 26. PMID:27599864<ref>PMID:27599864</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 5b7w" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv.campestris
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