5bka
From Proteopedia
(Difference between revisions)
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==2.1 Angstrom structure of ActVI-ORFA from Streptomyces Coelicolor== | ==2.1 Angstrom structure of ActVI-ORFA from Streptomyces Coelicolor== | ||
| - | <StructureSection load='5bka' size='340' side='right'caption='[[5bka]] | + | <StructureSection load='5bka' size='340' side='right'caption='[[5bka]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BKA FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bka OCA], [https://pdbe.org/5bka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bka RCSB], [https://www.ebi.ac.uk/pdbsum/5bka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bka ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bka OCA], [https://pdbe.org/5bka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bka RCSB], [https://www.ebi.ac.uk/pdbsum/5bka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bka ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/Q7AKI2_STRCO Q7AKI2_STRCO] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Proteins belonging to the NTF2-like superfamily are present in the biosynthetic pathways of numerous polyketide natural products, such as anthracyclins and benzoisochromanequinones. Some have been found to be bona fide polyketide cyclases, but many of them have roles that are currently unknown. Here, the X-ray crystal structures of three NTF2-like proteins of unknown function are reported: those of ActVI-ORFA from Streptomyces coelicolor A3(2) and its homologs Caci_6494, a protein from an uncharacterized biosynthetic cluster in Catenulispora acidiphila, and Aln2 from Streptomyces sp. CM020, a protein in the biosynthetic pathway of alnumycin. The presence of a solvent-accessible cavity and the conservation of the His/Asp dyad that is characteristic of many polyketide cyclases suggest a potential enzymatic role for these enzymes in polyketide biosynthesis. | ||
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| - | Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis.,Vuksanovic N, Zhu X, Serrano DA, Siitonen V, Metsa-Ketela M, Melancon CE 3rd, Silvaggi NR Acta Crystallogr F Struct Biol Commun. 2020 Aug 1;76(Pt 8):372-383. doi:, 10.1107/S2053230X20009814. Epub 2020 Jul 29. PMID:32744249<ref>PMID:32744249</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 5bka" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Vuksanovic, N, Silvaggi, N]] | |
| - | [[Category: Vuksanovic N]] | + | |
Current revision
2.1 Angstrom structure of ActVI-ORFA from Streptomyces Coelicolor
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