1ki0
From Proteopedia
(New page: 200px<br /> <applet load="1ki0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ki0, resolution 1.75Å" /> '''The X-ray Structure...) |
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| - | [[Image:1ki0.gif|left|200px]]<br /> | + | [[Image:1ki0.gif|left|200px]]<br /><applet load="1ki0" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ki0" size=" | + | |
caption="1ki0, resolution 1.75Å" /> | caption="1ki0, resolution 1.75Å" /> | ||
'''The X-ray Structure of Human Angiostatin'''<br /> | '''The X-ray Structure of Human Angiostatin'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Angiogenesis inhibitors have gained much public attention recently as | + | Angiogenesis inhibitors have gained much public attention recently as anti-cancer agents and several are currently in clinical trials, including angiostatin (Phase I, Thomas Jefferson University Hospital, Philadelphia, PA). We report here the bowl-shaped structure of angiostatin kringles 1-3, the first multi-kringle structure to be determined. All three kringle lysine-binding sites contain a bound bicine molecule of crystallization while the former of kringle 2 and kringle 3 are cofacial. Moreover, the separation of the kringle 2 and kringle 3 lysiner binding sites is sufficient to accommodate the alpha-helix of the 30 residue peptide VEK-30 found in the kringle 2/VEK-30 complex. Together the three kringles produce a central cavity suggestive of a unique domain where they may function in concert. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1KI0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with BCN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Plasmin Plasmin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.7 3.4.21.7] Full crystallographic information is available from [http:// | + | 1KI0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BCN:'>BCN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Plasmin Plasmin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.7 3.4.21.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KI0 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Plasmin]] | [[Category: Plasmin]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Abad, M | + | [[Category: Abad, M C.]] |
| - | [[Category: Arni, R | + | [[Category: Arni, R K.]] |
| - | [[Category: Castellino, F | + | [[Category: Castellino, F J.]] |
| - | [[Category: Geiger, J | + | [[Category: Geiger, J H.]] |
| - | [[Category: Grella, D | + | [[Category: Grella, D K.]] |
[[Category: Tulinsky, A.]] | [[Category: Tulinsky, A.]] | ||
[[Category: BCN]] | [[Category: BCN]] | ||
[[Category: kringle domains]] | [[Category: kringle domains]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:34:22 2008'' |
Revision as of 11:34, 21 February 2008
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The X-ray Structure of Human Angiostatin
Contents |
Overview
Angiogenesis inhibitors have gained much public attention recently as anti-cancer agents and several are currently in clinical trials, including angiostatin (Phase I, Thomas Jefferson University Hospital, Philadelphia, PA). We report here the bowl-shaped structure of angiostatin kringles 1-3, the first multi-kringle structure to be determined. All three kringle lysine-binding sites contain a bound bicine molecule of crystallization while the former of kringle 2 and kringle 3 are cofacial. Moreover, the separation of the kringle 2 and kringle 3 lysiner binding sites is sufficient to accommodate the alpha-helix of the 30 residue peptide VEK-30 found in the kringle 2/VEK-30 complex. Together the three kringles produce a central cavity suggestive of a unique domain where they may function in concert.
Disease
Known diseases associated with this structure: Conjunctivitis, ligneous OMIM:[173350], Plasminogen Tochigi disease OMIM:[173350], Plasminogen deficiency, types I and II OMIM:[173350], Thrombophilia, dysplasminogenemic OMIM:[173350]
About this Structure
1KI0 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Plasmin, with EC number 3.4.21.7 Full crystallographic information is available from OCA.
Reference
The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin., Abad MC, Arni RK, Grella DK, Castellino FJ, Tulinsky A, Geiger JH, J Mol Biol. 2002 May 10;318(4):1009-17. PMID:12054798
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