We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
User:Daniel Key Takemoto/Sandbox 1
From Proteopedia
(Difference between revisions)
(New page: ==Function and Structure== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> Fragile X messenger ribonucleoprotein (FMRP) is encoded by t...) |
|||
| Line 1: | Line 1: | ||
==Function and Structure== | ==Function and Structure== | ||
| - | <StructureSection load=' | + | <StructureSection load='4QVZ' size='340' side='right' caption='Caption for this structure' scene=''> |
Fragile X messenger ribonucleoprotein (FMRP) is encoded by the fragile X messenger ribonucleoprotein 1 (FMR1) gene, located in the X chromossome, associated with the fragile X syndrome, Fragile X Tremor/Ataxia Syndrome (FXTAS) and Premature Ovarian Failure (POF1). The FMRP binds to RNAs and its own FMR1 transcripts, possibly a self-regulatory mechanism. A motif that is going to be explored is the RGG motif, that the protein uses to bind to guanine G-quadruplexes a structure that consists of nucleic acid folding in which four guanines arrange in a planar conformation stabilized by Hoogsteen-trype hydrogen bonds, named tetrad. | Fragile X messenger ribonucleoprotein (FMRP) is encoded by the fragile X messenger ribonucleoprotein 1 (FMR1) gene, located in the X chromossome, associated with the fragile X syndrome, Fragile X Tremor/Ataxia Syndrome (FXTAS) and Premature Ovarian Failure (POF1). The FMRP binds to RNAs and its own FMR1 transcripts, possibly a self-regulatory mechanism. A motif that is going to be explored is the RGG motif, that the protein uses to bind to guanine G-quadruplexes a structure that consists of nucleic acid folding in which four guanines arrange in a planar conformation stabilized by Hoogsteen-trype hydrogen bonds, named tetrad. | ||
Revision as of 17:16, 9 June 2023
Function and Structure
| |||||||||||
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
