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1l1h

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{{STRUCTURE_1l1h| PDB=1l1h | SCENE= }}
{{STRUCTURE_1l1h| PDB=1l1h | SCENE= }}
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'''Crystal Structure of the Quadruplex DNA-Drug Complex'''
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===Crystal Structure of the Quadruplex DNA-Drug Complex===
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==Overview==
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Stabilisation of G-quadruplex structures formed from telomeric DNA, by means of quadruplex-selective ligands, is a means of inhibiting the telomerase enzyme from catalysing the synthesis of telomeric DNA repeats. In order to understand the molecular basis of ligand-quadruplex recognition, the crystal structure has been determined of such a complex, at 1.75A resolution. This complex is between a dimeric antiparallel G-quadruplex formed from the Oxytricha nova telomeric DNA sequence d(GGGGTTTTGGGG), and a di-substituted aminoalkylamido acridine compound. The structure shows that the acridine moiety is bound at one end of the stack of G-quartets, within one of the thymine loops. It is held in place by a combination of stacking interactions and specific hydrogen bonds with thymine bases. The stability of the ligand in this binding site has been confirmed by a 2ns molecular dynamics simulation.
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(as it appears on PubMed at http://www.pubmed.gov), where 12547195 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12547195}}
==About this Structure==
==About this Structure==
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[[Category: G-quadruplex]]
[[Category: G-quadruplex]]
[[Category: Oxytricha]]
[[Category: Oxytricha]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:25:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:29:23 2008''

Revision as of 08:29, 2 July 2008

Image:1l1h.png

Template:STRUCTURE 1l1h

Crystal Structure of the Quadruplex DNA-Drug Complex

Template:ABSTRACT PUBMED 12547195

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a G-quadruplex-ligand complex., Haider SM, Parkinson GN, Neidle S, J Mol Biol. 2003 Feb 7;326(1):117-25. PMID:12547195

Page seeded by OCA on Wed Jul 2 11:29:23 2008

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