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8j8t
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of calcium-saturated SRCR domain 11 of DMBT1== | |
| - | + | <StructureSection load='8j8t' size='340' side='right'caption='[[8j8t]], [[Resolution|resolution]] 1.81Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8j8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J8T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j8t OCA], [https://pdbe.org/8j8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j8t RCSB], [https://www.ebi.ac.uk/pdbsum/8j8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j8t ProSAT]</span></td></tr> |
| - | [[Category: Lu | + | </table> |
| - | [[Category: Zhang | + | == Disease == |
| + | [https://www.uniprot.org/uniprot/DMBT1_HUMAN DMBT1_HUMAN] The gene represented in this entry is involved in disease pathogenesis. Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DMBT1_HUMAN DMBT1_HUMAN] May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.<ref>PMID:10485905</ref> <ref>PMID:11007786</ref> <ref>PMID:11751412</ref> <ref>PMID:16796526</ref> <ref>PMID:17548659</ref> <ref>PMID:17709527</ref> <ref>PMID:19189310</ref> <ref>PMID:9288095</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lu P]] | ||
| + | [[Category: Nagata K]] | ||
| + | [[Category: Zhang C]] | ||
Current revision
Crystal structure of calcium-saturated SRCR domain 11 of DMBT1
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