1l1w

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[[Image:1l1w.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1l1w| PDB=1l1w | SCENE= }}
{{STRUCTURE_1l1w| PDB=1l1w | SCENE= }}
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'''NMR structure of a SRP19 binding domain in human SRP RNA'''
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===NMR structure of a SRP19 binding domain in human SRP RNA===
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==Overview==
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Assembly of the human signal recognition particle (SRP) requires SRP19 protein to bind to helices 6 and 8 of SRP RNA. In the present study, structure of a 29-mer RNA composing the SRP19 binding site in helix 6 was determined by NMR spectroscopy. The two A:C mismatches were continuously stacked to each other and formed wobble type A:C base pairs. The GGAG tetraloop in helix 6 was found to adopt a similar conformation to that of GNRA tetraloop, suggesting that these tetraloops are included in an extensive new motif GNRR. Compared with the crystal structure of helix 6 in complex with SRP19 determined previously, the GGAG tetraloop in the complex was found to adopt a similar conformation to the free form, although the loop structure becomes more open upon SRP19 binding. Thus, SRP19 is thought to recognize the overall fold of the GGAG loop.
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The line below this paragraph, {{ABSTRACT_PUBMED_12153712}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12153712 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12153712}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1W OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1W OCA].
==Reference==
==Reference==
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[[Category: Rna hairpin]]
[[Category: Rna hairpin]]
[[Category: Tetraloop]]
[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:26:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:31:09 2008''

Revision as of 08:31, 2 July 2008

Image:1l1w.png

Template:STRUCTURE 1l1w

NMR structure of a SRP19 binding domain in human SRP RNA

Template:ABSTRACT PUBMED 12153712

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of a SRP19 binding domain in human SRP RNA., Sakamoto T, Morita S, Tabata K, Nakamura K, Kawai G, J Biochem. 2002 Aug;132(2):177-82. PMID:12153712

Page seeded by OCA on Wed Jul 2 11:31:09 2008

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