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1l2h

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{{STRUCTURE_1l2h| PDB=1l2h | SCENE= }}
{{STRUCTURE_1l2h| PDB=1l2h | SCENE= }}
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'''Crystal structure of Interleukin 1-beta F42W/W120F mutant'''
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===Crystal structure of Interleukin 1-beta F42W/W120F mutant===
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==Overview==
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The crystal structure at 1.54 A resolution of a double mutant of interleukin-1beta (F42W/W120F), a cytokine secreted by macrophages, was determined by multiple-wavelength anomalous dispersion (MAD) using data from highly twinned selenomethionine-modified crystals. The space group is P4(3), with unit-cell parameters a = b = 53.9, c = 77.4 A. Self-rotation function analysis and various intensity statistics revealed the presence of merohedral twinning in crystals of both the native (twinning fraction alpha approximately 0.35) and SeMet (alpha approximately 0.40) forms. Structure determination and refinement are discussed with emphasis on the possible reasons for successful phasing using untreated twinned MAD data.
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(as it appears on PubMed at http://www.pubmed.gov), where 12554939 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12554939}}
==About this Structure==
==About this Structure==
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[[Category: Mad phasing]]
[[Category: Mad phasing]]
[[Category: Protein folding]]
[[Category: Protein folding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:27:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:33:09 2008''

Revision as of 08:33, 2 July 2008

Image:1l2h.png

Template:STRUCTURE 1l2h

Crystal structure of Interleukin 1-beta F42W/W120F mutant

Template:ABSTRACT PUBMED 12554939

About this Structure

1L2H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta., Rudolph MG, Kelker MS, Schneider TR, Yeates TO, Oseroff V, Heidary DK, Jennings PA, Wilson IA, Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):290-8. Epub 2003, Jan 23. PMID:12554939

Page seeded by OCA on Wed Jul 2 11:33:09 2008

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