1kl9
From Proteopedia
(New page: 200px<br /> <applet load="1kl9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kl9, resolution 1.90Å" /> '''Crystal structure o...) |
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caption="1kl9, resolution 1.90Å" /> | caption="1kl9, resolution 1.90Å" /> | ||
'''Crystal structure of the N-terminal segment of Human eukaryotic initiation factor 2alpha'''<br /> | '''Crystal structure of the N-terminal segment of Human eukaryotic initiation factor 2alpha'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1KL9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1KL9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KL9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ob fold]] | [[Category: ob fold]] | ||
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Revision as of 14:14, 15 February 2008
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Crystal structure of the N-terminal segment of Human eukaryotic initiation factor 2alpha
Contents |
Overview
Eukaryotic translation initiation factor 2alpha (eIF2alpha) is a member of, the eIF2 heterotrimeric complex that binds and delivers Met-tRNA(i)(Met), to the 40 S ribosomal subunit in a GTP-dependent manner., Phosphorylation/dephosphorylation of eIF2alpha at Ser-51 is the major, regulator of protein synthesis in eukaryotic cells. Here, we report the, first structural analysis on eIF2, the three-dimensional structure of a, 22-kDa N-terminal portion of human eIF2alpha by x-ray diffraction at 1.9 A, resolution. This structure contains two major domains. The N terminus is a, beta-barrel with five antiparallel beta-strands in an oligonucleotide, binding domain (OB domain) fold. The phosphorylation site (Ser-51) is on, the loop connecting beta3 and beta4 in the OB domain. A helical domain, follows the OB domain, and the first helix has extensive interactions, including a disulfide bridge, to fix its orientation with respect to the, OB domain. The two domains meet along a negatively charged groove with, highly conserved residues, indicating a likely site for protein-protein, interaction.
Disease
Known disease associated with this structure: Wolcott-Rallison syndrome OMIM:[604032]
About this Structure
1KL9 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha., Nonato MC, Widom J, Clardy J, J Biol Chem. 2002 May 10;277(19):17057-61. Epub 2002 Feb 21. PMID:11859078
Page seeded by OCA on Fri Feb 15 16:14:26 2008
Categories: Homo sapiens | Single protein | Clardy, J. | Nonato, M.C. | Widom, J. | ZN | Helical domain | Ob fold
