7bcj

<table><tr><td colspan='2'>[[7bcj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cutibacterium_acnes_KPA171202 Cutibacterium acnes KPA171202]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BCJ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bcj OCA], [https://pdbe.org/7bcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bcj RCSB], [https://www.ebi.ac.uk/pdbsum/7bcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bcj ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/Q6A6F6_CUTAK Q6A6F6_CUTAK]

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== Publication Abstract from PubMed ==

Cutibacterium acnes is a predominant bacterium on human skin and is generally regarded as commensal. Recently, the abundantly secreted protein produced by C. acnes, RoxP, was shown to alleviate radical-induced cell damage, presumably via antioxidant activity, which could potentially be harnessed to fortify skin barrier function. The aim of this study was to determine the structure of RoxP and elucidate the mechanisms behind its antioxidative effect. Here, we present the solution structure of RoxP revealing a compact immunoglobulin-like domain containing a long flexible loop which, in concert with the core domain, forms a positively charged groove that could function as a binding site for cofactors or substrates. Although RoxP shares structural features with cell-adhesion proteins, we show that it does not appear to be responsible for adhesion of C. acnes bacteria to human keratinocytes. We identify two tyrosine-containing stretches located in the flexible loop of RoxP, which appear to be responsible for the antioxidant activity of RoxP.

Solution Structure of the Cutibacterium acnes-Specific Protein RoxP and Insights Into Its Antioxidant Activity.,Stodkilde K, Nielsen JT, Petersen SV, Paetzold B, Bruggemann H, Mulder FAA, Andersen CBF Front Cell Infect Microbiol. 2022 Feb 11;12:803004. doi:, 10.3389/fcimb.2022.803004. eCollection 2022. PMID:35223541<ref>PMID:35223541</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

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[[Category: Cutibacterium acnes KPA171202]]