7ofn

<table><tr><td colspan='2'>[[7ofn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OFN FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ofn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ofn OCA], [https://pdbe.org/7ofn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ofn RCSB], [https://www.ebi.ac.uk/pdbsum/7ofn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ofn ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/Q63UZ9_BURPS Q63UZ9_BURPS]

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== Publication Abstract from PubMed ==

The SYLF domain is an evolutionary conserved protein domain with phosphatidylinositol binding ability, whose three-dimensional structure is unknown. Here, we present the solution structure and the dynamics characterization of the SYLF domain of the bacterial BPSL1445 protein. BPSL1445 is a seroreactive antigen and a diagnostic marker of Burkholderia pseudomallei, the etiological agent of melioidosis, a severe infectious disease in the tropics. The BPSL1445 SYLF domain (BPSL1445-SYLF) consists of a beta-barrel core, with two flexible loops protruding out of the barrel and three helices packing on its surface. Our structure allows for a more precise definition of the boundaries of the SYLF domain compared to the previously reported one and suggests common ancestry with bacterial EipA domains. We also demonstrate by phosphatidyl-inositol phosphate arrays and nuclear magnetic resonance titrations that BPSL1445-SYLF weakly interacts with phosphoinositides, thus supporting lipid binding abilities of this domain also in prokaryotes.

Solution Structure of the BPSL1445 Protein of Burkholderia pseudomallei Reveals the SYLF Domain Three-Dimensional Fold.,Quilici G, Berardi A, Fabris C, Ghitti M, Punta M, Gourlay LJ, Bolognesi M, Musco G ACS Chem Biol. 2022 Jan 21;17(1):230-239. doi: 10.1021/acschembio.1c00886. Epub, 2021 Dec 30. PMID:34968022<ref>PMID:34968022</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Burkholderia pseudomallei]]