7qi2
From Proteopedia
(Difference between revisions)
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<StructureSection load='7qi2' size='340' side='right'caption='[[7qi2]]' scene=''> | <StructureSection load='7qi2' size='340' side='right'caption='[[7qi2]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QI2 FirstGlance]. <br> |
- | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qi2 OCA], [https://pdbe.org/7qi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qi2 RCSB], [https://www.ebi.ac.uk/pdbsum/7qi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qi2 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr> |
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qi2 OCA], [https://pdbe.org/7qi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qi2 RCSB], [https://www.ebi.ac.uk/pdbsum/7qi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qi2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
- | == Function == | ||
- | [https://www.uniprot.org/uniprot/VDAC1_HUMAN VDAC1_HUMAN] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:11845315</ref> <ref>PMID:15033708</ref> <ref>PMID:18755977</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Andreas LB]] | [[Category: Andreas LB]] | ||
[[Category: Najbauer EE]] | [[Category: Najbauer EE]] |
Current revision
Magic-angle spinning NMR structure of the human voltage-dependent anion channel 1 (E73V/C127A/C232S) in DMPC lipid bilayers
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