7qi2

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Current revision (06:17, 19 June 2024) (edit) (undo)
 
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<StructureSection load='7qi2' size='340' side='right'caption='[[7qi2]]' scene=''>
<StructureSection load='7qi2' size='340' side='right'caption='[[7qi2]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7qi2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QI2 FirstGlance]. <br>
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<table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QI2 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qi2 OCA], [https://pdbe.org/7qi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qi2 RCSB], [https://www.ebi.ac.uk/pdbsum/7qi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qi2 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qi2 OCA], [https://pdbe.org/7qi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qi2 RCSB], [https://www.ebi.ac.uk/pdbsum/7qi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qi2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[https://www.uniprot.org/uniprot/VDAC1_HUMAN VDAC1_HUMAN] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:11845315</ref> <ref>PMID:15033708</ref> <ref>PMID:18755977</ref>
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Andreas LB]]
[[Category: Andreas LB]]
[[Category: Najbauer EE]]
[[Category: Najbauer EE]]

Current revision

Magic-angle spinning NMR structure of the human voltage-dependent anion channel 1 (E73V/C127A/C232S) in DMPC lipid bilayers

PDB ID 7qi2

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