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1l8k

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{{STRUCTURE_1l8k| PDB=1l8k | SCENE= }}
{{STRUCTURE_1l8k| PDB=1l8k | SCENE= }}
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'''T Cell Protein-Tyrosine Phosphatase Structure'''
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===T Cell Protein-Tyrosine Phosphatase Structure===
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==Overview==
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Protein-tyrosine phosphatase 1B (PTP1B) has recently received much attention as a potential drug target in type 2 diabetes. This has in particular been spurred by the finding that PTP1B knockout mice show increased insulin sensitivity and resistance to diet-induced obesity. Surprisingly, the highly homologous T cell protein-tyrosine phosphatase (TC-PTP) has received much less attention, and no x-ray structure has been provided. We have previously co-crystallized PTP1B with a number of low molecular weight inhibitors that inhibit TC-PTP with similar efficiency. Unexpectedly, we were not able to co-crystallize TC-PTP with the same set of inhibitors. This seems to be due to a multimerization process where residues 130-132, the DDQ loop, from one molecule is inserted into the active site of the neighboring molecule, resulting in a continuous string of interacting TC-PTP molecules. Importantly, despite the high degree of functional and structural similarity between TC-PTP and PTP1B, we have been able to identify areas close to the active site that might be addressed to develop selective inhibitors of each enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 11907034 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11907034}}
==About this Structure==
==About this Structure==
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[[Category: Iversen, L F.]]
[[Category: Iversen, L F.]]
[[Category: Protein tyrosine phosphatase]]
[[Category: Protein tyrosine phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:39:59 2008''
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Revision as of 08:57, 2 July 2008

Image:1l8k.png

Template:STRUCTURE 1l8k

T Cell Protein-Tyrosine Phosphatase Structure

Template:ABSTRACT PUBMED 11907034

About this Structure

1L8K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure determination of T cell protein-tyrosine phosphatase., Iversen LF, Moller KB, Pedersen AK, Peters GH, Petersen AS, Andersen HS, Branner S, Mortensen SB, Moller NP, J Biol Chem. 2002 May 31;277(22):19982-90. Epub 2002 Mar 20. PMID:11907034

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