1l8q

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[[Image:1l8q.gif|left|200px]]
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{{Seed}}
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[[Image:1l8q.png|left|200px]]
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{{STRUCTURE_1l8q| PDB=1l8q | SCENE= }}
{{STRUCTURE_1l8q| PDB=1l8q | SCENE= }}
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'''CRYSTAL STRUCTURE OF DNA REPLICATION INITIATION FACTOR'''
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===CRYSTAL STRUCTURE OF DNA REPLICATION INITIATION FACTOR===
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==Overview==
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The initiation of DNA replication is a key event in the cell cycle of all organisms. In bacteria, replication initiation occurs at specific origin sequences that are recognized and processed by an oligomeric complex of the initiator protein DnaA. We have determined the structure of the conserved core of the Aquifex aeolicus DnaA protein to 2.7 A resolution. The protein comprises an AAA+ nucleotide-binding fold linked through a long, helical connector to an all-helical DNA-binding domain. The structure serves as a template for understanding the physical consequences of a variety of DnaA mutations, and conserved motifs in the protein suggest how two critical aspects of origin processing, DNA binding and homo-oligomerization, are mediated. The spatial arrangement of these motifs in DnaA is similar to that of the eukaryotic-like archaeal replication initiation factor Cdc6/Orc1, demonstrating that mechanistic elements of origin processing may be conserved across bacterial, archaeal and eukaryotic domains of life.
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The line below this paragraph, {{ABSTRACT_PUBMED_12234917}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12234917 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12234917}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Replication initiation]]
[[Category: Replication initiation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:40:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:57:49 2008''

Revision as of 08:57, 2 July 2008

Image:1l8q.png

Template:STRUCTURE 1l8q

CRYSTAL STRUCTURE OF DNA REPLICATION INITIATION FACTOR

Template:ABSTRACT PUBMED 12234917

About this Structure

1L8Q is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiation., Erzberger JP, Pirruccello MM, Berger JM, EMBO J. 2002 Sep 16;21(18):4763-73. PMID:12234917

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