8j7n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:19, 1 May 2024) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8j7n is ON HOLD until Paper Publication
+
==The cryo-EM structure of Fe3+ induced alpha-syn fibril.==
-
 
+
<StructureSection load='8j7n' size='340' side='right'caption='[[8j7n]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
Authors: Zhao, Q.Y., Tao, Y.Q., Yan, F., Liu, C., Li, D.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8j7n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J7N FirstGlance]. <br>
-
Description: The cryo-EM structure of Fe3+ induced alpha-syn fibril.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j7n OCA], [https://pdbe.org/8j7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j7n RCSB], [https://www.ebi.ac.uk/pdbsum/8j7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j7n ProSAT]</span></td></tr>
-
[[Category: Li, D]]
+
</table>
-
[[Category: Liu, C]]
+
== Disease ==
-
[[Category: Yan, F]]
+
[https://www.uniprot.org/uniprot/T106B_HUMAN T106B_HUMAN] Progressive non-fluent aphasia;Semantic dementia;Behavioral variant of frontotemporal dementia. The gene represented in this entry acts as a disease modifier. Risk alleles confer genetic susceptibility by increasing gene expression (PubMed:20154673, PubMed:21178100). Increased expression may be the result of down-regulation of microRNA miR-132 and miR-212, that repress TMEM106B expression (PubMed:22895706). Thr-185 is a risk allele associated with lower GRN protein levels and early age at onset in GRN UP-FTD mutation carriers: it presents slower protein degradation that leads to higher steady-state TMEM106B levels, leading to alterations in the intracellular versus extracellular partitioning of GRN (PubMed:23742080).<ref>PMID:20154673</ref> <ref>PMID:21178100</ref> <ref>PMID:22895706</ref> <ref>PMID:23742080</ref> The gene represented in this entry acts as a disease modifier. The disease may be caused by variants affecting the gene represented in this entry.
-
[[Category: Zhao, Q.Y]]
+
== Function ==
-
[[Category: Tao, Y.Q]]
+
[https://www.uniprot.org/uniprot/T106B_HUMAN T106B_HUMAN] Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.<ref>PMID:23136129</ref> <ref>PMID:24357581</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Li D]]
 +
[[Category: Liu C]]
 +
[[Category: Tao YQ]]
 +
[[Category: Yan F]]
 +
[[Category: Zhao QY]]

Current revision

The cryo-EM structure of Fe3+ induced alpha-syn fibril.

PDB ID 8j7n

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8j7n"
Personal tools