8j9a
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of ABD3 (residues 453-561) of human MED15 isoform 2== | |
| - | + | <StructureSection load='8j9a' size='340' side='right'caption='[[8j9a]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8j9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J9A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j9a OCA], [https://pdbe.org/8j9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j9a RCSB], [https://www.ebi.ac.uk/pdbsum/8j9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j9a ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Li | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MED15_HUMAN MED15_HUMAN] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.<ref>PMID:12167862</ref> <ref>PMID:16630888</ref> <ref>PMID:16799563</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Zhang H]] | ||
Revision as of 08:28, 9 May 2024
Solution structure of ABD3 (residues 453-561) of human MED15 isoform 2
| |||||||||||
