8jbc

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Current revision (11:45, 13 December 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8jbc is ON HOLD until Paper Publication
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==Crystal Structure of the Csm6 K137A mutant from Thermus thermophilus HB8 in its apo form==
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<StructureSection load='8jbc' size='340' side='right'caption='[[8jbc]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8jbc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JBC FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jbc OCA], [https://pdbe.org/8jbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jbc RCSB], [https://www.ebi.ac.uk/pdbsum/8jbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jbc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSM6_THET8 CSM6_THET8] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (Probable). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities. This protein is not part of the Csm effector complex (Probable). A single-strand-specific endoribonuclease (ssRNase) producing free 5'-OH (PubMed:26763118). Activity is approximately 1000-fold stimulated by cyclic oligoadenylate (cOA); only cyclic tetraadenylate (cA4) stimulates the ssRNase activity while linear oligoadenylates do not activate the RNase (PubMed:28663439). Another study showed stimulation by linear tetraadenylate at very high concentrations, but did not examine stimulation by cA4 (PubMed:28722012).<ref>PMID:26763118</ref> <ref>PMID:28663439</ref> <ref>PMID:28722012</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Du L]]
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[[Category: Lin Z]]

Current revision

Crystal Structure of the Csm6 K137A mutant from Thermus thermophilus HB8 in its apo form

PDB ID 8jbc

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