8ou1
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the SPOC domain of mouse SPOCD1== | |
| - | + | <StructureSection load='8ou1' size='340' side='right'caption='[[8ou1]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ou1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OU1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ou1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ou1 OCA], [https://pdbe.org/8ou1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ou1 RCSB], [https://www.ebi.ac.uk/pdbsum/8ou1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ou1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SPOC1_MOUSE SPOC1_MOUSE] Essential excecutor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (PubMed:32674113). Associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (PubMed:32674113). Tethering of PIWIL4 to a nascent transposable element transcript recruits repressive chromatin remodeling activities and the de novo methylation apparatus through SPOCD1 (PubMed:32674113). Not required for piRNA biosynthesis (PubMed:32674113).<ref>PMID:32674113</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Cook AG]] | ||
| + | [[Category: Heep M]] | ||
| + | [[Category: O'Carroll D]] | ||
Current revision
Crystal structure of the SPOC domain of mouse SPOCD1
| |||||||||||
