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8t55
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654== | |
| - | + | <StructureSection load='8t55' size='340' side='right'caption='[[8t55]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8t55]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T55 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZI3:N-[3-(4-chlorophenyl)oxetan-3-yl]-1-propanoyl-1,2,3,4-tetrahydroquinoline-5-carboxamide'>ZI3</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t55 OCA], [https://pdbe.org/8t55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t55 RCSB], [https://www.ebi.ac.uk/pdbsum/8t55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t55 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/WDR91_HUMAN WDR91_HUMAN] Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB:Q7TMQ7]<ref>PMID:26783301</ref> <ref>PMID:27126989</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Ackloo S]] |
| - | [[Category: | + | [[Category: Ahmad H]] |
| - | [[Category: Xu | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Brown PJ]] |
| - | [[Category: | + | [[Category: Dong A]] |
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Feng JW]] | ||
| + | [[Category: Halabelian L]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Santhakumar V]] | ||
| + | [[Category: Seitova A]] | ||
| + | [[Category: Xu J]] | ||
| + | [[Category: Yen H]] | ||
| + | [[Category: Zeng H]] | ||
Current revision
Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654
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Categories: Homo sapiens | Large Structures | Ackloo S | Ahmad H | Arrowsmith CH | Brown PJ | Dong A | Edwards AM | Feng JW | Halabelian L | Li Y | Santhakumar V | Seitova A | Xu J | Yen H | Zeng H
