8t5i

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m (Protected "8t5i" [edit=sysop:move=sysop])
Current revision (05:32, 9 August 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8t5i is ON HOLD
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==Crystal structure of human WDR5 in complex with MR4397==
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<StructureSection load='8t5i' size='340' side='right'caption='[[8t5i]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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Authors: Kimani, S., Dong, A., Li, F., Loppnau, P., Ackloo, S., Vedadi, M., Brown, P.J., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8t5i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T5I FirstGlance]. <br>
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Description: Crystal structure of human WDR5 in complex with MR4397
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZHF:N-[(2S)-1-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-1-oxopentan-2-yl]-3-[(1H-imidazol-1-yl)methyl]benzamide'>ZHF</scene></td></tr>
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[[Category: Dong, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t5i OCA], [https://pdbe.org/8t5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t5i RCSB], [https://www.ebi.ac.uk/pdbsum/8t5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t5i ProSAT]</span></td></tr>
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[[Category: Vedadi, M]]
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</table>
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[[Category: Halabelian, L]]
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== Function ==
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[[Category: Li, F]]
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[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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[[Category: Loppnau, P]]
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== References ==
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[[Category: Arrowsmith, C.H]]
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<references/>
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[[Category: Brown, P.J]]
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__TOC__
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[[Category: Ackloo, S]]
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</StructureSection>
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[[Category: Edwards, A.M]]
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[[Category: Homo sapiens]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Large Structures]]
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[[Category: Kimani, S]]
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[[Category: Ackloo S]]
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[[Category: Arrowsmith CH]]
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[[Category: Brown PJ]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Halabelian L]]
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[[Category: Kimani S]]
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[[Category: Li F]]
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[[Category: Loppnau P]]
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[[Category: Vedadi M]]

Current revision

Crystal structure of human WDR5 in complex with MR4397

PDB ID 8t5i

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