1l9z

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[[Image:1l9z.jpg|left|200px]]
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{{Seed}}
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[[Image:1l9z.png|left|200px]]
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{{STRUCTURE_1l9z| PDB=1l9z | SCENE= }}
{{STRUCTURE_1l9z| PDB=1l9z | SCENE= }}
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'''Thermus aquaticus RNA Polymerase Holoenzyme/Fork-Junction Promoter DNA Complex at 6.5 A Resolution'''
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===Thermus aquaticus RNA Polymerase Holoenzyme/Fork-Junction Promoter DNA Complex at 6.5 A Resolution===
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==Overview==
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The crystal structure of Thermus aquaticus RNA polymerase holoenzyme (alpha2betabeta'omegasigmaA) complexed with a fork-junction promoter DNA fragment has been determined by fitting high-resolution x-ray structures of individual components into a 6.5-angstrom resolution map. The DNA lies across one face of the holoenzyme, completely outside the RNA polymerase active site channel. All sequence-specific contacts with core promoter elements are mediated by the sigma subunit. A universally conserved tryptophan is ideally positioned to stack on the exposed face of the base pair at the upstream edge of the transcription bubble. Universally conserved basic residues of the sigma subunit provide critical contacts with the DNA phosphate backbone and play a role in directing the melted DNA template strand into the RNA polymerase active site. The structure explains how holoenzyme recognizes promoters containing variably spaced -10 and -35 elements and provides the basis for models of the closed and open promoter complexes.
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The line below this paragraph, {{ABSTRACT_PUBMED_12016307}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12016307 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12016307}}
==About this Structure==
==About this Structure==
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[[Category: Coiled-coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:42:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:04:47 2008''

Revision as of 09:04, 2 July 2008

Image:1l9z.png

Template:STRUCTURE 1l9z

Thermus aquaticus RNA Polymerase Holoenzyme/Fork-Junction Promoter DNA Complex at 6.5 A Resolution

Template:ABSTRACT PUBMED 12016307

About this Structure

1L9Z is a Protein complex structure of sequences from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex., Murakami KS, Masuda S, Campbell EA, Muzzin O, Darst SA, Science. 2002 May 17;296(5571):1285-90. PMID:12016307

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